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Laterality
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=== In mice === In mice (''Mus musculus''), laterality in paw usage has been shown to be a learned behavior (rather than inherited),<ref>{{Cite journal|last1=Biddle|first1=Fred G|last2=Eales|first2=Brenda A| year = 2006 |title=Hand-preference training in the mouse reveals key elements of its learning and memory process and resolves the phenotypic complexity in the behaviour|journal=Genome|language=en|volume=49|issue=6|pages=666β677|doi=10.1139/g06-026|pmid=16936846|issn=0831-2796}}</ref> due to which, in any population, half of the mice become left-handed while the other half becomes right-handed. The learning occurs by a gradual reinforcement of randomly occurring weak asymmetries in paw choice early in training, even when training in an unbiased world.<ref name=":0">{{Cite journal|last1=Ribeiro|first1=Andre S.|last2=Lloyd-Price|first2=Jason|last3=Eales|first3=Brenda A.|last4=Biddle|first4=Fred G.|year = 2010|title=Dynamic Agent-Based Model of Hand-Preference Behavior Patterns in the Mouse|journal=Adaptive Behavior|language=en|volume=18|issue=2|pages=116β131|doi=10.1177/1059712309339859|s2cid=10117297|issn=1059-7123}}</ref><ref name=":1">{{Cite journal|last1=Ribeiro|first1=Andre S.|last2=Eales|first2=Brenda A.|last3=Biddle|first3=Fred G.|year = 2011|title=Learning of paw preference in mice is strain dependent, gradual and based on short-term memory of previous reaches|journal=Animal Behaviour|language=en|volume=81|issue=1|pages=249β257|doi=10.1016/j.anbehav.2010.10.014|s2cid=26136740}}</ref> Meanwhile, reinforcement relies on short-term and long-term memory skills that are strain-dependent,<ref name=":0" /><ref name=":1" /> causing strains to differ in the degree of laterality of its individuals. Long-term memory of previously gained laterality in handedness due to training is heavily diminished in mice with absent corpus callosum and reduced hippocampal commissure.<ref>{{Cite journal|last1=Ribeiro|first1=Andre S.|last2=Eales|first2=Brenda A.|last3=Biddle|first3=Fred G.|year = 2013|title=Short-term and long-term memory deficits in handedness learning in mice with absent corpus callosum and reduced hippocampal commissure|journal=Behavioural Brain Research|language=en|volume=245|pages=145β151|doi=10.1016/j.bbr.2013.02.021|pmid=23454853|s2cid=40650630}}</ref> Regardless of the amount of past training and consequent biasing of paw choice, there is a degree of randomness in paw choice that is not removed by training,<ref>{{Cite journal|last1=Ribeiro|first1=Andre S.|last2=Eales|first2=Brenda A.|last3=Lloyd-Price|first3=Jason|last4=Biddle|first4=Fred G.|year = 2014|title=Predictability and randomness of paw choices are critical elements in the behavioural plasticity of mouse paw preference|journal=Animal Behaviour|language=en|volume=98|pages=167β176|doi=10.1016/j.anbehav.2014.10.008|s2cid=53144817}}</ref> which may provide adaptability to changing environments.
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