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Lectin
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===Bacteria and viruses=== Some [[hepatitis C]] viral glycoproteins may attach to [[C-type lectin]]s on the host cell surface (liver cells) to initiate infection.<ref>{{cite journal |author=R. Bartenschlager |author2=S. Sparacio |title=Hepatitis C Virus Molecular Clones and Their Replication Capacity in Vivo and in Cell Culture |journal=Virus Research |volume=127 |issue=2 |pages=195β207 |year=2007 |doi=10.1016/j.virusres.2007.02.022 |pmid=17428568}}</ref> To avoid clearance from the body by the [[innate immune system]], pathogens (e.g., [[virus]] particles and [[bacteria]] that infect human cells) often express surface lectins known as [[adhesins]] and [[hemagglutinin]]s that bind to tissue-specific [[glycans]] on host cell-surface glycoproteins and [[glycolipids]].<ref>{{cite journal |pmid=9973330 |pmc=93481 |title=Bacterial adhesins: common themes and variations in architecture and assembly |journal=J Bacteriol |volume=181 |issue=4 |pages=1059β1071 |year=1999 |last1=Soto |first1=GE |last2=Hultgren |first2=SJ |doi=10.1128/JB.181.4.1059-1071.1999}}</ref> Multiple viruses, including [[influenza]] and several viruses in the [[Paramyxoviridae]] family, use this mechanism to bind and gain entry to target cells.<ref>{{Cite journal| doi = 10.1128/JVI.76.24.13028-13033.2002| issn = 0022-538X| volume = 76| issue = 24| pages = 13028β13033| last1 = Takimoto| first1 = Toru| last2 = Taylor| first2 = Garry L.| last3 = Connaris| first3 = Helen C.| last4 = Crennell| first4 = Susan J.| last5 = Portner| first5 = Allen| title = Role of the Hemagglutinin-Neuraminidase Protein in the Mechanism of Paramyxovirus-Cell Membrane Fusion| journal = Journal of Virology| date = 2002| pmid = 12438628| pmc = 136693}}</ref>
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