Editing Leptin (section)

=== Fetal lung ===
In [[fetal lung]], leptin is induced in the alveolar interstitial fibroblasts ("lipofibroblasts") by the action of [[PTHrP]] secreted by formative alveolar epithelium ([[endoderm]]) under moderate stretch. The leptin from the [[mesenchyme]], in turn, acts back on the epithelium at the leptin receptor carried in the alveolar type II pneumocytes and induces surfactant expression, which is one of the main functions of these type II pneumocytes.<ref name="pmid16940239">{{cite journal | vauthors = Torday JS, Rehan VK | title = Up-regulation of fetal rat lung parathyroid hormone-related protein gene regulatory network down-regulates the Sonic Hedgehog/Wnt/betacatenin gene regulatory network | journal = Pediatric Research | volume = 60 | issue = 4 | pages = 382–388 | date = October 2006 | pmid = 16940239 | doi = 10.1203/01.pdr.0000238326.42590.03 | s2cid = 21101408 | doi-access = free }}</ref>