Editing Liposarcoma (section)

====Pathology====
[[File:Histopathology of an atypical lipomatous tumor or well-differentiated liposarcoma, lipoma-like subtype.jpg|thumb|ALT/WDL, adipocytic/lipoma-like. At low magnification, the tumor mostly contains adipocytes that appear benign and mature, but high magnification of one fibrous band shows abnormal spindle-shaped cells with enlarged, [[heterochromatic]] nuclei.]]

Histopathologically, ALT/WDL tumors are divided into adipocytic/lipoma-like, sclerosing, and inflammatory variants with adipocyte/lipoma-like being the most common. Adipocytic/lipoma-like ALT/WDL tumors consist of lobules of mature fat cells variably intersected with irregular fibrous [[Septum|septa]] (see the adjacent [[H&E stain]]ed [[photomicrograph]]). Sclerosing ALT/WDL tumors, the second most common variant, develop primarily in the retroperitoneal and paratesticular areas; it consists of scattered, atypical [[stromal cell]]s within a collagenous (i.e. [[collagen]]-containing) [[Stroma (tissue)|stromal tissue]] background. Rare [[vacuole]]-containing [[lipoblast]]s  populate this tissue. Inflammatory ALT/WDL tumors are the rarest variant. they occur most frequently in the retroperitoneum and consists of [[Inflammation#Chronic inflammation|chronic inflammatory]] cells, e.g. [[lymphocytes]] and [[plasma cells]] plus occasional [[Lymph node|lymph node-like follicles]] interspersed throughout a tissue background containing [[fat cells]].<ref name="pmid32991496"/>