Editing Locus coeruleus (section)

==Function==
It is related to many functions via its widespread projections. The LC-NA system modulates cortical, subcortical, cerebellar, brainstem, and spinal cord circuits. Some of the most important functions influenced by this system are:<ref name="pmid19917994">{{cite journal | author = Benarroch EE | title = The locus ceruleus norepinephrine system: functional organization and potential clinical significance | journal = Neurology | volume = 73 | issue = 20 | pages = 1699–704 |date=November 2009  | pmid = 19917994 | doi = 10.1212/WNL.0b013e3181c2937c | s2cid = 28805417 }}</ref><ref name="Malenka pathways">{{cite book |vauthors=Malenka RC, Nestler EJ, Hyman SE |veditors=Sydor A, Brown RY | title = Molecular Neuropharmacology: A Foundation for Clinical Neuroscience | year = 2009 | publisher = McGraw-Hill Medical | location = New York | isbn = 9780071481274 | page = 157 | edition = 2nd | chapter = Chapter 6: Widely Projecting Systems: Monoamines, Acetylcholine, and Orexin}}</ref>
* [[Arousal]] and [[sleep-wake cycle]]
* [[Attention]]<ref>{{Cite journal|last1=Bouret|first1=Sebastien|last2=Sara|first2=Susan J.|date=2005|title=Network reset: a simplified overarching theory of locus coeruleus noradrenaline function|url=http://dx.doi.org/10.1016/j.tins.2005.09.002|journal=Trends in Neurosciences|volume=28|issue=11|pages=574–582|doi=10.1016/j.tins.2005.09.002|pmid=16165227|s2cid=205403074|issn=0166-2236|url-access=subscription}}</ref> and [[memory]]
* Behavioral and [[cognitive flexibility]],<ref>{{Cite journal|last1=Beversdorf|first1=D Q.|last2=Hughes|first2=J D.|last3=Steinberg|first3=B A.|last4=Lewis|first4=L D.|last5=Heilman|first5=K M.|date=1999|title=Noradrenergic modulation of cognitive flexibility in problem solving|url=https://dx.doi.org/10.1097%2F00001756-199909090-00012|journal=NeuroReport|language=en|volume=10|issue=13|pages=2763–2767|doi=10.1097/00001756-199909090-00012|pmid=10511436|issn=0959-4965|url-access=subscription}}</ref> [[creativity]],<ref>{{Cite journal|last1=Lin|first1=Hause|last2=Vartanian|first2=Oshin|date=2018|title=A Neuroeconomic Framework for Creative Cognition|url=http://journals.sagepub.com/doi/10.1177/1745691618794945|journal=Perspectives on Psychological Science|language=en|volume=13|issue=6|pages=655–677|doi=10.1177/1745691618794945|pmid=30304640|s2cid=206778956|issn=1745-6916}}</ref> behavioral inhibition and [[stress (psychological)]]
* [[Cognitive control]]
* [[Decision-making|Decision making]] and utility maximization<ref>{{Cite journal|last1=Aston-Jones|first1=Gary|last2=Cohen|first2=Jonathan D.|date=2005-07-21|title=An integrative theory of locus coeruleus-norepinephrine function: Adaptive gain and optimal performance|url=http://dx.doi.org/10.1146/annurev.neuro.28.061604.135709|journal=Annual Review of Neuroscience|volume=28|issue=1|pages=403–450|doi=10.1146/annurev.neuro.28.061604.135709|pmid=16022602|s2cid=535645 |issn=0147-006X|url-access=subscription}}</ref>
* [[Emotions]]
* [[Neuroplasticity]]
* Posture and [[balance (ability)|balance]]
* Global model failure where predictions about the world are strongly violated<ref name="c485">{{cite journal |last=Jordan |first=Rebecca |date=2024 |title=The locus coeruleus as a global model failure system |journal=Trends in Neurosciences |volume=47 |issue=2 |pages=92–105 |doi=10.1016/j.tins.2023.11.006|doi-access=free |pmid=38102059 }}</ref>
The locus coeruleus is a part of the [[reticular activating system]], and is almost completely inactivated in [[rapid eye movement sleep]].<ref name="Schwartz 2008">{{cite journal|last=Schwartz|first=JR|author2=Roth, T |title=Neurophysiology of sleep and wakefulness: basic science and clinical implications.|journal=Current Neuropharmacology|date=December 2008|volume=6|issue=4|pages=367–78|pmid=19587857|doi=10.2174/157015908787386050|pmc=2701283}}</ref>