Editing Loperamide (section)

===Pregnancy and breast feeding===
Loperamide is not recommended in the United Kingdom for use during [[pregnancy]] or by [[breastfeeding|nursing mothers]].<ref>{{cite web|url=http://www.nhs.uk/medicine-guides/pages/MedicineOverview.aspx?condition=Diarrhoea&medicine=imodium|title=Medicines information links - NHS Choices|access-date=14 May 2016|url-status=dead|archive-url=https://web.archive.org/web/20140110171045/http://www.nhs.uk/medicine-guides/pages/MedicineOverview.aspx?condition=Diarrhoea&medicine=imodium|archive-date=10 January 2014}}</ref> Studies in rat models have shown no [[teratogen]]icity, but sufficient studies in humans have not been conducted.<ref>{{cite web|url=http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search.Label_ApprovalHistory#labelinfo|title=Drugs@FDA: FDA Approved Drug Products|publisher=U.S. [[Food and Drug Administration]] (FDA) |access-date=14 May 2016|url-status=dead|archive-url=https://web.archive.org/web/20160506041852/http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search.Label_ApprovalHistory#labelinfo|archive-date=6 May 2016}}</ref> One controlled, prospective study of 89 women exposed to loperamide during their first trimester of pregnancy showed no increased risk of malformations. This, however, was only one study with a small sample size.<ref>{{cite journal | vauthors = Einarson A, Mastroiacovo P, Arnon J, Ornoy A, Addis A, Malm H, Koren G | title = Prospective, controlled, multicentre study of loperamide in pregnancy | journal = Canadian Journal of Gastroenterology | volume = 14 | issue = 3 | pages = 185–7 | date = March 2000 | pmid = 10758415 | doi = 10.1155/2000/957649 | doi-access = free }}</ref> Loperamide can be present in breast milk and is not recommended for breastfeeding mothers.<ref name=accessdata.fda.gov/>