Editing Mefenamic acid (section)

== Interactions ==

Interactions are broadly similar to those of other NSAIDs. Mefenamic acid interferes with the anti–blood clotting mechanism of Aspirin. It increases the [[Anticoagulant|blood thinning]] effects of [[warfarin]] and [[phenprocoumon]] because it displaces them from their [[plasma protein]] binding and increases their free concentrations in the bloodstream. It adds to the risk of gastrointestinal ulcera associated with [[corticosteroid]]s and [[selective serotonin reuptake inhibitor]]s. It can increase the risk for adverse effects of [[methotrexate]] and [[lithium (medication)|lithium]] by lowering their excretion via the kidneys. It can increase the kidney toxicity of [[ciclosporin]] and [[tacrolimus]]. Combination with [[antihypertensive drug]]s such as [[ACE inhibitor]]s, [[sartan]]s and [[diuretic]]s can decrease their effectiveness as well as increase the risk for kidney toxicity.<ref name="AustriaCodex" /><ref name="mediQ">{{cite web|url=https://www.mediq.ch/|title=mediQ: Mefenaminsäure|access-date=2020-07-23}}</ref>