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Monohybrid cross
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===Third cross=== Mendel then allowed some of each phenotype in the F2 generation to self-pollinate. His results: * All the wrinkled seeds in the F2 generation produced only wrinkled seeds in the F3. * One-third (193/565) of the round F1 seeds produced only round seeds in the F3 generation, but two-thirds (372/565) of them produced both types of seeds in the F3 and—once again—in a 3:1 ratio. One-third of the round seeds and all of the wrinkled seeds in the F2 generation were homozygous and produced only seeds of the same phenotype. But two thirds of the round seeds in the F2 were heterozygous and their self-pollination produced both phenotypes in the ratio of a typical F1 cross. Phenotype ratios are approximate.<ref>{{Cite journal|last=Piegorsch|first=W. W.|date=1990-12-01|title=Fisher's contributions to genetics and heredity, with special emphasis on the Gregor Mendel controversy|journal=Biometrics|volume=46|issue=4|pages=915–924|issn=0006-341X|pmid=2085640|doi=10.2307/2532437|jstor=2532437|url=https://zenodo.org/record/1235119 }}</ref> The union of sperm and eggs is random. As the size of the sample gets larger, however, chance deviations become minimized and the ratios approach the theoretical predictions more closely. The table shows the actual seed production by ten of Mendel's F1 plants. While his individual plants deviated widely from the expected 3:1 ratio, the group as a whole approached it quite closely. {| class="wikitable" border="5" |- ! Round ! Wrinkled |- | 45 | 12 |- | 27 | 8 |- | 24 | 7 |- | 19 | 16 |- | 32 | 11 |- | 26 | 6 |- | 88 | 24 |- | 22 | 10 |- | 28 | 6 |- | 25 | 7 |- | '''Total: 336''' | '''Total: 107''' |}
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