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===Roman lead poisoning hypothesis=== Geochemist Jerome Nriagu published an article in the ''[[New England Journal of Medicine]]'' in 1983 hypothesizing that defrutum and ''sapa'' may have contained enough [[Lead(II) acetate|lead acetate]] to be [[Lead poisoning|toxic]] to those who consumed them regularly.<ref name=Grout2011>{{cite web |url=http://penelope.uchicago.edu/~grout/encyclopaedia_romana/wine/leadpoisoning.html |archive-url=https://wayback.archive-it.org/all/20171019110206/http://penelope.uchicago.edu/~grout/encyclopaedia_romana/wine/leadpoisoning.html |url-status=dead |archive-date=19 October 2017 |title=Lead Poisoning and Rome |first=James |last=Grout |publisher=University of Chicago |access-date=22 July 2011}}</ref>
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