Editing Nitric oxide synthase (section)

=== nNOS ===

[[Neuron]]al NOS (nNOS) produces NO in [[nervous tissue]] in both the central and peripheral [[nervous systems]]. Its functions include:<ref>{{cite journal|last1=Förstermann|first1=Ulrich|last2=Sessa|first2=William|title=Nitric oxide synthases: regulation and function|journal=European Heart Journal|date=Apr 2012|volume=33|issue=7|pages=829–837|pmc=3345541|doi=10.1093/eurheartj/ehr304|pmid=21890489}}</ref>

* Synaptic plasticity in the central nervous system (CNS)
* Smooth muscle relaxation
* Central regulation of blood pressure
* Vasodilatation via peripheral nitrergic nerves

Neuronal NOS also performs a role in cell communication and is associated with plasma membranes. nNOS action can be inhibited by NPA ([[N-propyl-L-arginine]]). This form of the enzyme is specifically inhibited by [[7-Nitroindazole|7-nitroindazole]].<ref name="pmid8619882">{{cite journal |vauthors=Southan GJ, Szabó C | title = Selective pharmacological inhibition of distinct nitric oxide synthase isoforms | journal = Biochem. Pharmacol. | volume = 51 | issue = 4 | pages = 383–94 |date=February 1996 | pmid = 8619882 | doi = 10.1016/0006-2952(95)02099-3 }}</ref>

The subcellular localisation of nNOS in skeletal muscle is mediated by anchoring of nNOS to [[dystrophin]]. nNOS contains an additional N-terminal domain, the [[PDZ domain]].<ref name="pmid7535955">{{cite journal |vauthors=Ponting CP, Phillips C | title = DHR domains in syntrophins, neuronal NO synthases and other intracellular proteins | journal = Trends Biochem. Sci. | volume = 20 | issue = 3 | pages = 102–3 |date=March 1995 | pmid = 7535955 | doi = 10.1016/S0968-0004(00)88973-2 }}</ref>

The gene coding for nNOS is located on Chromosome 12.<ref name="Nitric oxide synthases in mammals">{{cite journal |vauthors=Knowles RG, Moncada S | title = Nitric oxide synthases in mammals | journal = Biochem. J. | volume = 298 | issue = 2| pages = 249–58 |date=March 1994 | pmid = 7510950 | pmc = 1137932 | doi =  10.1042/bj2980249}}</ref>