Editing Nociceptor (section)

===Thermal===
Thermal nociceptors are activated by noxious heat or cold at various temperatures. There are specific nociceptor transducers that are responsible for how and if the specific nerve ending responds to the thermal stimulus. The first to be discovered was [[TRPV1]], and it has a threshold that coincides with the heat pain temperature of 43&nbsp;°C. Other temperature in the warm–hot range is mediated by more than one [[Transient receptor potential channel|TRP channel]]. Each of these channels express a particular C-terminal domain that corresponds to the warm–hot sensitivity. The interactions between all these channels and how the temperature level is determined to be above the [[pain threshold]] are unknown at this time. The cool stimuli are sensed by [[TRPM8]] channels. Its C-terminal domain differs from the heat sensitive TRPs. Although this channel corresponds to cool stimuli, it is still unknown whether it also contributes in the detection of intense cold. An interesting finding related to cold stimuli is that tactile sensibility and motor function deteriorate while pain perception persists.