Editing Non-coding RNA (section)

===In DNA replication===

[[File:YRNA-Ro60.png|thumb|250px|The [[TRIM21|Ro autoantigen]] protein (white) binds the end of a double-stranded Y RNA (red) and a single stranded RNA (blue). (PDB: 1YVP [http://www.rcsb.org/pdb/explore.do?structureId=1yvp]).<ref name="pmid15907467">{{cite journal | vauthors = Stein AJ, Fuchs G, Fu C, Wolin SL, Reinisch KM | title = Structural insights into RNA quality control: the Ro autoantigen binds misfolded RNAs via its central cavity | journal = Cell | volume = 121 | issue = 4 | pages = 529–539 | date = May 2005 | pmid = 15907467 | pmc = 1769319 | doi = 10.1016/j.cell.2005.03.009 }}</ref>]]

[[Y RNA]]s are stem loops, necessary for [[DNA replication]] through interactions with [[chromatin]] and initiation proteins (including the [[origin recognition complex]]).<ref name="pmid16943439">{{cite journal | vauthors = Christov CP, Gardiner TJ, Szüts D, Krude T | title = Functional requirement of noncoding Y RNAs for human chromosomal DNA replication | journal = Molecular and Cellular Biology | volume = 26 | issue = 18 | pages = 6993–7004 | date = September 2006 | pmid = 16943439 | pmc = 1592862 | doi = 10.1128/MCB.01060-06 }}</ref><ref>{{cite journal | vauthors = Zhang AT, Langley AR, Christov CP, Kheir E, Shafee T, Gardiner TJ, Krude T | title = Dynamic interaction of Y RNAs with chromatin and initiation proteins during human DNA replication | journal = Journal of Cell Science | volume = 124 | issue = Pt 12 | pages = 2058–2069 | date = June 2011 | pmid = 21610089 | pmc = 3104036 | doi = 10.1242/jcs.086561 }}</ref> They are also components of the [[TRIM21|Ro60 ribonucleoprotein particle]]<ref>{{cite journal | vauthors = Hall AE, Turnbull C, Dalmay T | title = Y RNAs: recent developments | journal = Biomolecular Concepts | volume = 4 | issue = 2 | pages = 103–110 | date = April 2013 | pmid = 25436569 | doi = 10.1515/bmc-2012-0050 | s2cid = 12575326 | doi-access = free }}</ref> which is a target of autoimmune antibodies in patients with [[systemic lupus erythematosus]].<ref>{{cite journal | vauthors = Lerner MR, Boyle JA, Hardin JA, Steitz JA | title = Two novel classes of small ribonucleoproteins detected by antibodies associated with lupus erythematosus | journal = Science | volume = 211 | issue = 4480 | pages = 400–402 | date = January 1981 | pmid = 6164096 | doi = 10.1126/science.6164096 | bibcode = 1981Sci...211..400L }}</ref>