Editing Notch signaling pathway (section)

=== Synthetic Notch signaling ===

It is possible to engineer synthetic Notch receptors by replacing the extracellular receptor and intracellular transcriptional domains with other domains of choice. This allows researchers to select which ligands are detected, and which genes are upregulated in response. Using this technology, cells can report or change their behavior in response to contact with user-specified signals, facilitating new avenues of both basic and applied research into cell-cell signaling.<ref name="Harmansa">{{cite journal | vauthors = Harmansa S, Affolter M | title = Protein binders and their applications in developmental biology | journal = Development | volume = 145 | issue = 2 | pages = dev148874 | date = January 2018 | pmid = 29374062 | doi = 10.1242/dev.148874 | doi-access = free }}</ref> Notably, this system allows multiple synthetic pathways to be engineered into a cell in parallel.<ref>{{cite journal | vauthors = Themeli M, Sadelain M | title = Combinatorial Antigen Targeting: Ideal T-Cell Sensing and Anti-Tumor Response | journal = Trends in Molecular Medicine | volume = 22 | issue = 4 | pages = 271–273 | date = April 2016 | pmid = 26971630 | pmc = 4994806 | doi = 10.1016/j.molmed.2016.02.009 }}</ref><ref>{{cite journal | vauthors = Sadelain M | title = Chimeric antigen receptors: driving immunology towards synthetic biology | journal = Current Opinion in Immunology | volume = 41 | pages = 68–76 | date = August 2016 | pmid = 27372731 | pmc = 5520666 | doi = 10.1016/j.coi.2016.06.004 }}</ref>