Editing Paracetamol (section)

====Headaches====

Paracetamol is effective for acute migraine:<ref name="pmid25600718">{{cite journal |vauthors=Marmura MJ, Silberstein SD, Schwedt TJ |title=The acute treatment of migraine in adults: the american headache society evidence assessment of migraine pharmacotherapies |journal=Headache |volume=55 |issue=1 |pages=3–20 |date=January 2015 |pmid= 25600718 |doi=10.1111/head.12499 |s2cid=25576700}}</ref> 39% of people experience pain relief at one hour compared with 20% in the control group.<ref>{{cite journal |vauthors= Derry S, Moore RA |title=Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults |journal=Cochrane Database Syst Rev |volume=4 |issue= 4|pages= CD008040 |year=2013 |pmid=23633349 |doi=10.1002/14651858.CD008040.pub3 |pmc=4161111}}</ref> The aspirin/paracetamol/caffeine combination also "has strong evidence of effectiveness and can be used as a [[Therapy#Lines of therapy|first-line treatment]] for migraine".<ref name="pmid29671521">{{Cite journal |vauthors=Mayans L, Walling A |date=February 2018 |title=Acute Migraine Headache: Treatment Strategies |url=https://www.aafp.org/pubs/afp/issues/2018/0215/p243.html |journal=Am Fam Physician |volume=97 |issue=4 |pages=243–251 |pmid=29671521}}</ref> Paracetamol on its own only slightly alleviates episodic [[tension headache]] in those who have them frequently.<ref name="pmid27306653">{{cite journal |vauthors=Stephens G, Derry S, Moore RA |title=Paracetamol (acetaminophen) for acute treatment of episodic tension-type headache in adults |journal=Cochrane Database Syst Rev |volume= 2019|issue=6 |pages=CD011889 |date=June 2016 |pmid=27306653 |pmc=6457822 |doi=10.1002/14651858.CD011889.pub2}}</ref> However, the aspirin/paracetamol/caffeine combination is superior to both paracetamol alone and placebo and offers meaningful relief of tension headache: two hours after administering the medication, 29% of those who took the combination were pain-free as compared with 21% on paracetamol and 18% on placebo.<ref name="pmid25406671">{{cite journal |vauthors=Diener HC, Gold M, Hagen M |title=Use of a fixed combination of acetylsalicylic acid, acetaminophen and caffeine compared with acetaminophen alone in episodic tension-type headache: meta-analysis of four randomized, double-blind, placebo-controlled, crossover studies |journal=J Headache Pain |volume=15 |issue= 1|pages=76 |date=November 2014 |pmid=25406671 |pmc=4256978 |doi=10.1186/1129-2377-15-76 |doi-access=free }}</ref> The German, Austrian, and Swiss headache societies and the German Society of Neurology recommend this combination as a "highlighted" one for self-medication of tension headache, with paracetamol/caffeine combination being a "remedy of first choice", and paracetamol a "remedy of second choice".<ref name="pmid21181425">{{cite journal |vauthors=Haag G, Diener HC, May A, Meyer C, Morck H, Straube A, Wessely P, Evers S |title=Self-medication of migraine and tension-type headache: summary of the evidence-based recommendations of the Deutsche Migräne und Kopfschmerzgesellschaft (DMKG), the Deutsche Gesellschaft für Neurologie (DGN), the Österreichische Kopfschmerzgesellschaft (ÖKSG) and the Schweizerische Kopfwehgesellschaft (SKG) |journal=J Headache Pain |volume=12 |issue=2 |pages=201–217 |date=April 2011 |pmid=21181425 |pmc=3075399 |doi=10.1007/s10194-010-0266-4}}</ref>