Editing Peroxisome proliferator-activated receptor (section)

== Structure ==
Like other nuclear receptors, PPARs are modular in structure and contain the following [[protein domains|functional domains]]:
* (A/B) -  [[N-terminus|N-terminal region]]
* (C) ''DBD'' - [[DNA-binding domain]]
* (D) - flexible [[Molecular hinge|hinge]] region
* (E) ''LBD'' - [[ligand binding domain]]
* (F) [[C-terminus|C-terminal region]]

The DBD contains two [[zinc finger]] motifs, which bind to specific sequences of DNA known as [[hormone response element]]s when the receptor is activated.

The LBD has an extensive [[secondary structure]] consisting of 13 [[alpha helix|alpha helices]] and a [[beta sheet]].<ref name="pmid17317294">{{cite journal | vauthors = Zoete V, Grosdidier A, Michielin O | title = Peroxisome proliferator-activated receptor structures: ligand specificity, molecular switch and interactions with regulators | journal = Biochim. Biophys. Acta | volume = 1771 | issue = 8 | pages = 915–25 | year = 2007 | pmid = 17317294 | doi = 10.1016/j.bbalip.2007.01.007 }}</ref>  Both natural and synthetic ligands can bind to the LBD, either [[agonist|activating]] or [[receptor antagonist|repressing]] the receptor's activity.