Editing Pharmacogenomics (section)

==== Drug transporters ====
Many medications rely on [[transport protein|transporters]] to cross cellular membranes in order to move between body fluid compartments such as the blood, gut lumen, bile, urine, brain, and cerebrospinal fluid.<ref name=":1">{{cite journal | vauthors = Nigam SK | title = What do drug transporters really do? | journal = Nature Reviews. Drug Discovery | volume = 14 | issue = 1 | pages = 29–44 | date = January 2015 | pmid = 25475361 | pmc = 4750486 | doi = 10.1038/nrd4461 }}</ref> The major transporters include the [[Solute carrier family|solute carrier]], [[ATP-binding cassette transporter|ATP-binding cassette]], and [[Organo anion transporter family|organic anion transporters]].<ref name=":1" /> Transporters that have been shown to influence response to medications include [[OATP1B1]] (''SLCO1B1'') and breast cancer resistance protein (BCRP) (''[[ABCG2]]).''<ref>{{Cite journal |last1=Cooper-DeHoff |first1=Rhonda M. |last2=Niemi |first2=Mikko |last3=Ramsey |first3=Laura B. |last4=Luzum |first4=Jasmine A. |last5=Tarkiainen |first5=E. Katriina |last6=Straka |first6=Robert J. |last7=Gong |first7=Li |last8=Tuteja |first8=Sony |last9=Wilke |first9=Russell A. |last10=Wadelius |first10=Mia |last11=Larson |first11=Eric A. |last12=Roden |first12=Dan M. |last13=Klein |first13=Teri E. |last14=Yee |first14=Sook Wah |last15=Krauss |first15=Ronald M. |date=May 2022 |title=The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1, ABCG2, and CYP2C9 genotypes and Statin-Associated Musculoskeletal Symptoms |journal=Clinical Pharmacology and Therapeutics |volume=111 |issue=5 |pages=1007–1021 |doi=10.1002/cpt.2557 |issn=1532-6535 |pmc=9035072 |pmid=35152405}}</ref>