Editing Plasmin (section)

== Interactions ==

Plasmin has been shown to [[Protein–protein interaction|interact]] with [[Thrombospondin 1]],<ref name=pmid6438154>{{cite journal | vauthors = Silverstein RL, Leung LL, Harpel PC, Nachman RL | title = Complex formation of platelet thrombospondin with plasminogen. Modulation of activation by tissue activator | journal = The Journal of Clinical Investigation | volume = 74 | issue = 5 | pages = 1625–1633 | date = November 1984 | pmid = 6438154 | pmc = 425339 | doi = 10.1172/JCI111578 }}</ref><ref name=pmid2522013>{{cite journal | vauthors = DePoli P, Bacon-Baguley T, Kendra-Franczak S, Cederholm MT, Walz DA | title = Thrombospondin interaction with plasminogen. Evidence for binding to a specific region of the kringle structure of plasminogen | journal = Blood | volume = 73 | issue = 4 | pages = 976–982 | date = March 1989 | pmid = 2522013 | doi = 10.1182/blood.V73.4.976.976 | doi-access = free }}</ref> [[Alpha 2-antiplasmin]]<ref name=pmid158022>{{cite journal | vauthors = Wiman B, Collen D | title = On the mechanism of the reaction between human alpha 2-antiplasmin and plasmin | journal = The Journal of Biological Chemistry | volume = 254 | issue = 18 | pages = 9291–9297 | date = September 1979 | pmid = 158022 | doi = 10.1016/S0021-9258(19)86843-6 | doi-access = free }}</ref><ref name=pmid2437112>{{cite journal | vauthors = Shieh BH, Travis J | title = The reactive site of human alpha 2-antiplasmin | journal = The Journal of Biological Chemistry | volume = 262 | issue = 13 | pages = 6055–6059 | date = May 1987 | pmid = 2437112 | doi = 10.1016/S0021-9258(18)45536-6 | doi-access = free }}</ref> and [[IGFBP3]].<ref name=pmid9688635>{{cite journal | vauthors = Campbell PG, Durham SK, Suwanichkul A, Hayes JD, Powell DR | title = Plasminogen binds the heparin-binding domain of insulin-like growth factor-binding protein-3 | journal = The American Journal of Physiology | volume = 275 | issue = 2 | pages = E321–E331 | date = August 1998 | pmid = 9688635 | doi = 10.1152/ajpendo.1998.275.2.E321 }}</ref> Moreover, plasmin induces the generation of [[bradykinin]] in mice and humans through [[high-molecular-weight kininogen]] cleavage.<ref>{{cite journal | vauthors = Marcos-Contreras OA, Martinez de Lizarrondo S, Bardou I, Orset C, Pruvost M, Anfray A, Frigout Y, Hommet Y, Lebouvier L, Montaner J, Vivien D, Gauberti M | display-authors = 6 | title = Hyperfibrinolysis increases blood-brain barrier permeability by a plasmin- and bradykinin-dependent mechanism | journal = Blood | volume = 128 | issue = 20 | pages = 2423–2434 | date = November 2016 | pmid = 27531677 | doi = 10.1182/blood-2016-03-705384 | doi-access = free }}</ref>