Editing Polyketide (section)

=== Post-tailoring enzymes ===
Further possible modifications to the polyketide scaffolds can be made. This can include glycosylation via a [[glucosyltransferase]] or oxidation via a [[monooxygenase]].<ref>{{cite journal | vauthors = Risdian C, Mozef T, Wink J | title = Biosynthesis of Polyketides in ''Streptomyces'' | journal = Microorganisms | volume = 7 | issue = 5 | pages = 124 | date = May 2019 | pmid = 31064143 | pmc = 6560455 | doi = 10.3390/microorganisms7050124 | doi-access = free}}</ref> Similarly, cyclization and aromatization can be introduced via a [[cyclase]], sometimes proceeded by the enol tautomers of the polyketide.<ref name="Robinson">{{cite journal | vauthors = Robinson JA | title = Polyketide synthase complexes: their structure and function in antibiotic biosynthesis | journal = Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences | volume = 332 | issue = 1263 | pages = 107–114 | date = May 1991 | pmid = 1678529 | doi = 10.1098/rstb.1991.0038 | bibcode = 1991RSPTB.332..107R | authorlink2 = Alan Fersht}}</ref> These enzymes are not part of the domains of the polyketide synthase. Instead, they are found in [[gene cluster]]s in the genome close to the polyketide synthase genes.<ref>{{cite journal | vauthors = Noar RD, Daub ME | title = Bioinformatics Prediction of Polyketide Synthase Gene Clusters from Mycosphaerella fijiensis | journal = PLOS ONE | volume = 11 | issue = 7 | pages = e0158471 | date = 2016-07-07 | pmid = 27388157 | pmc = 4936691 | doi = 10.1371/journal.pone.0158471 | bibcode = 2016PLoSO..1158471N | doi-access = free}}</ref>