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Pyridoxal phosphate
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==Catalytic mechanism== The pyridoxal-5β²-phosphate-dependent enzymes (PLP enzymes) catalyze myriad reactions. Although the scope of PLP-catalyzed reactions appears to be immense, the unifying principle is the formation of an internal lysine-derived aldimine. Once the amino substrate interacts with the active site, a new Schiff base is generated, commonly referred to as the external aldimine. After this step, the pathway for each PLP-catalyzed reactions diverge.<ref>{{cite journal | doi = 10.1146/annurev.biochem.73.011303.074021| title = Pyridoxal Phosphate Enzymes: Mechanistic, Structural, and Evolutionary Considerations| year = 2004| last1 = Eliot| first1 = Andrew C.| last2 = Kirsch| first2 = Jack F.| journal = Annual Review of Biochemistry| volume = 73| pages = 383β415| pmid = 15189147}}</ref> [[File:PLP mechanism.svg|800px|thumbnail|center|class=skin-invert-image|Mechanistic examples: racemization of alanine and elimination of cysteine.]]
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