Editing Quorum sensing (section)

====Gram-positive bacteria====
Gram-positive bacteria use [[Autoinducer#Peptides|autoinducing peptide]]s (AIP) as their autoinducers.<ref name=":2">{{cite journal | vauthors = Rutherford ST, Bassler BL | title = Bacterial quorum sensing: its role in virulence and possibilities for its control | journal = Cold Spring Harbor Perspectives in Medicine | volume = 2 | issue = 11 | pages = a012427 | date = November 2012 | pmid = 23125205 | pmc = 3543102 | doi = 10.1101/cshperspect.a012427 }}</ref>

When gram-positive bacteria detect high concentration of AIPs in their environment, that happens by way of AIPs binding to a receptor to activate a [[kinase]]. The kinase [[phosphorylation|phosphorylates]] a [[transcription factor]], which regulates gene transcription. This is called a [[two-component regulatory system|two-component system]].

Another possible mechanism is that AIP is transported into the [[cytosol]], and binds directly to a transcription factor to initiate or inhibit transcription.<ref name=":2" />