Editing RNA splicing (section)

==== Recursive splicing ====
In most cases, splicing removes introns as single units from precursor [[Messenger RNA|mRNA]] transcripts. However, in some cases, especially in mRNAs with very long introns, splicing happens in steps, with part of an intron removed and then the remaining intron is spliced out in a following step. This has been found first in the ''[[Ultrabithorax]]'' (''Ubx'') gene of the fruit fly, ''[[Drosophila melanogaster]]'', and a few other ''Drosophila'' genes, but cases in humans have been reported as well.<ref>{{cite journal | vauthors = Sibley CR, Emmett W, Blazquez L, Faro A, Haberman N, Briese M, Trabzuni D, Ryten M, Weale ME, Hardy J, Modic M, Curk T, Wilson SW, Plagnol V, Ule J | display-authors = 6 | title = Recursive splicing in long vertebrate genes | language = En | journal = Nature | volume = 521 | issue = 7552 | pages = 371–375 | date = May 2015 | pmid = 25970246 | pmc = 4471124 | doi = 10.1038/nature14466 | bibcode = 2015Natur.521..371S }}</ref><ref>{{cite journal | vauthors = Duff MO, Olson S, Wei X, Garrett SC, Osman A, Bolisetty M, Plocik A, Celniker SE, Graveley BR | display-authors = 6 | title = Genome-wide identification of zero nucleotide recursive splicing in Drosophila | language = En | journal = Nature | volume = 521 | issue = 7552 | pages = 376–379 | date = May 2015 | pmid = 25970244 | pmc = 4529404 | doi = 10.1038/nature14475 | bibcode = 2015Natur.521..376D }}</ref>