Editing Reuptake (section)

==Neuroprotective role==
[[Astrocytes]] seem to utilize reuptake mechanisms for a neuroprotective role. Astrocytes use [[EAAT2|excitatory amino acid transporter 2]] (EAAT2, aka GLT-1) to remove [[glutamate]] from the synapse. EAAT2 [[Knockout mouse|knockout mice]] were more prone to lethal and spontaneous seizures and acute brain injuries among the cortex. These effects could be linked to increased concentrations of glutamate in the brains of EAAT2 knockout mice, analyzed post-mortem.<ref>{{cite journal | vauthors = Tanaka K, Watase K, Manabe T, Yamada K, Watanabe M, Takahashi K, Iwama H, Nishikawa T, Ichihara N, Kikuchi T, Okuyama S, Kawashima N, Hori S, Takimoto M, Wada K | title = Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1 | journal = Science | volume = 276 | issue = 5319 | pages = 1699–702 | date = June 1997 | pmid = 9180080 | doi = 10.1126/science.276.5319.1699 }}</ref>