Editing Sarcoma (section)

==Cause==
=== Causes and risk factors ===
The cause of most '''bone sarcomas''' is not known,<ref name=":2">{{Cite book|title=DeVita, Hellman and Rosenberg's Cancer: Principles & Practice of Oncology | edition = 10th| vauthors = DeVita Jr V |publisher=Wolters Kluwer Health|year=2015|isbn=978-1-4511-9294-0|location=Philadelphia, PA|pages=1241–1313}}</ref> but several factors are associated with an increased risk of developing bone sarcoma. Previous exposure to ionizing radiation (such as prior radiation therapy) is one such risk factor.<ref name=":1" /> Therapeutic radiation is associated with sarcoma after 10 to 20 years.<ref>{{Cite web |title=UpToDate |url=https://www.uptodate.com/contents/radiation-associated-sarcomas#! |access-date=2023-03-19 |website=www.uptodate.com}}</ref> Exposure to alkylating agents, such as those found in [[Alkylating antineoplastic agent|certain cancer chemotherapeutic medicines]], also increases the risk of bone sarcoma.<ref name=":2" /> Certain inherited genetic syndromes, including [[Li–Fraumeni syndrome|Li-Fraumeni syndrome]], inherited ''RB1'' gene mutations, and [[Paget's disease of bone]] are associated with an increased risk of developing bone sarcomas.<ref name=":1" />

Most '''soft-tissue sarcomas''' arise from what doctors call "sporadic" (or random) genetic mutations within an affected person's cells.<ref name=":2" /> Nevertheless, there are certain risk factors associated with an increased risk of developing soft-tissue sarcoma. Previous exposure to [[ionizing radiation]] is one such risk factor.<ref name=":1" /> Exposure to vinyl chloride (e.g., such as the fumes encountered in the production of [[polyvinyl chloride]] (PVC)), [[arsenic]] and [[Thorotrast]] all are associated with an increased risk of angiosarcoma.<ref name=":1" /><ref name=":2" />  Lymphedema, such as that resulting from certain types of breast cancer treatment, also is a risk factor for development of angiosarcoma.<ref name=":2" /> As with bone sarcomas, certain inherited genetic syndromes also are associated with an increased risk of developing soft-tissue sarcoma, including [[Li–Fraumeni syndrome|Li-Fraumeni syndrome]], [[familial adenomatous polyposis]], [[Neurofibromatosis type I|neurofibromatosis type 1]], and heritable ''RB1'' gene mutations.<ref name=":2" /> [[Kaposi's sarcoma|Kaposi sarcoma]] is caused by [[Kaposi's sarcoma-associated herpesvirus|Kaposi sarcoma-associated herpesvirus]] (HHV-8).