Editing Signal peptide (section)

==Nucleotide level features==

In vertebrates, the region of the [[mRNA]] that codes for the signal peptide (i.e. the signal sequence coding region, or SSCR) can function as an RNA element with specific activities. SSCRs promote nuclear mRNA export and the proper localization to the surface of the endoplasmic reticulum. In addition SSCRs have specific sequence features: they have low [[adenine]]-content, are enriched in certain [[sequence motif|motifs]], and tend to be present in the first [[exon]] at a frequency that is higher than expected.<ref name="PalazzoSpringer2007">{{cite journal | vauthors = Palazzo AF, Springer M, Shibata Y, Lee CS, Dias AP, Rapoport TA | title = The signal sequence coding region promotes nuclear export of mRNA | journal = PLOS Biology | volume = 5 | issue = 12 | pages = e322 | date = December 2007 | pmid = 18052610 | pmc = 2100149 | doi = 10.1371/journal.pbio.0050322 | doi-access = free }}</ref><ref name="Cenik2011">{{cite journal | vauthors = Cenik C, Chua HN, Zhang H, Tarnawsky SP, Akef A, Derti A, Tasan M, Moore MJ, Palazzo AF, Roth FP | display-authors = 6 | title = Genome analysis reveals interplay between 5'UTR introns and nuclear mRNA export for secretory and mitochondrial genes | journal = PLOS Genetics | volume = 7 | issue = 4 | pages = e1001366 | date = April 2011 | pmid = 21533221 | pmc = 3077370 | doi = 10.1371/journal.pgen.1001366 | editor1-last = Snyder | editor1-first = Michael | doi-access = free }}</ref>