Editing Silent synapse (section)

== Integration with other topics ==
The Role of Silent Synapses in Long Term Potentiation

* Many of the mechanisms involved in [[Long-term potentiation|Long Term Potentiation]] are similar if not identical to those involved in silent synapse activation.<ref>{{cite journal | vauthors = Baltaci SB, Mogulkoc R, Baltaci AK | title = Molecular Mechanisms of Early and Late LTP | journal = Neurochemical Research | volume = 44 | issue = 2 | pages = 281–296 | date = February 2019 | pmid = 30523578 | doi = 10.1007/s11064-018-2695-4 | s2cid = 54447044 }}</ref>  Both processes require the recruitment of AMPA receptors to the synapse.

Neural Development

* During development there are certain [[Critical period|critical periods]] where sensory input is essential for correct development.<ref>{{cite journal | vauthors = Kanold PO, Deng R, Meng X | title = The Integrative Function of Silent Synapses on Subplate Neurons in Cortical Development and Dysfunction | language = en | journal = Frontiers in Neuroanatomy | volume = 13 | pages = 41 | date = 2019 | pmid = 31040772 | pmc = 6476909 | doi = 10.3389/fnana.2019.00041 | doi-access = free }}</ref>  This is necessary for sensory, motor, and cognitive functions.  Activating silent synapses helps build the [[Neural network|neural networks]] needed for this development.<ref>{{cite journal | vauthors = Huang X | title = Silent synapse: A new player in visual cortex critical period plasticity | journal = Pharmacological Research | volume = 141 | pages = 586–590 | date = March 2019 | pmid = 30659896 | doi = 10.1016/j.phrs.2019.01.031 | s2cid = 58546141 }}</ref>

AMPA Receptor Trafficking

* Because silent synapses are activated by the insertion of [[AMPA receptor|AMPAR's]], the trafficking of those receptors is highly applicable.  Evidence suggests that the main source of AMPA receptor recruitment in Long Term Potentiation comes from the endocytic/recycling pathway,<ref>{{cite journal | vauthors = Park M | title = AMPA Receptor Trafficking for Postsynaptic Potentiation | language = en | journal = Frontiers in Cellular Neuroscience | volume = 12 | pages = 361 | date = 2018 | pmid = 30364291 | pmc = 6193507 | doi = 10.3389/fncel.2018.00361 | doi-access = free }}</ref> but there is also evidence that [[Cell membrane|lateral membrane diffusion]] from extrasynaptic areas could also contribute to AMPAR recruitment.<ref>{{cite journal | vauthors = Kneussel M, Hausrat TJ | title = Postsynaptic Neurotransmitter Receptor Reserve Pools for Synaptic Potentiation | language = en | journal = Trends in Neurosciences | volume = 39 | issue = 3 | pages = 170–182 | date = March 2016 | pmid = 26833258 | doi = 10.1016/j.tins.2016.01.002 | s2cid = 3514596 | url = https://www.cell.com/trends/neurosciences/abstract/S0166-2236(16)00003-5 | url-access = subscription }}</ref>