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Sinus node dysfunction
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=== Extrinsic causes === Common cardiac pharmacology such as [[Beta blocker|beta-blockers]], [[calcium channel blocker]]s, [[digoxin]], sympatholytic medication, and other antiarrhythmics can alter sinus node function to create an arrhythmia such as sick sinus syndrome. Electrolyte abnormalities such as [[hyperkalemia]], [[hypokalemia]], and [[Hypocalcaemia|hypocalcemia]] can also alter normal sinus node functioning. [[Hypothyroidism]], [[Hypoxia (medical)|hypoxia]], [[hypothermia]], and various toxins have also been associated with sinus node dysfunctions.<ref name="Semelka20132" /><ref name="John2016" />
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