Editing Subcutaneous administration (section)

==Contraindications==
Contraindications to subcutaneous injections primarily depend on the specific medication being administered. Doses which would require more than 2 mL to be injected at once are not administered subcutaneously.<ref>{{cite journal | vauthors = Mathaes R, Koulov A, Joerg S, Mahler HC | title = Subcutaneous Injection Volume of Biopharmaceuticals-Pushing the Boundaries | journal = Journal of Pharmaceutical Sciences | volume = 105 | issue = 8 | pages = 2255–2259 | date = August 2016 | pmid = 27378678 | doi = 10.1016/j.xphs.2016.05.029 | name-list-style = vanc }}</ref> Medications which may cause necrosis or otherwise be damaging or irritating to tissues should also not be administered subcutaneously.<ref name="Prettyman">{{cite journal | vauthors = Prettyman J | title = Subcutaneous or intramuscular? Confronting a parenteral administration dilemma | journal = Medsurg Nursing | volume = 14 | issue = 2 | pages = 93–8; quiz 99 | date = April 2005 | pmid = 15916264 | name-list-style = vanc }}</ref> An injection should not be given at a specific site if there is inflammation or skin damage in the area.<ref>{{cite book | vauthors = Ballweg R, Brown DL, Vetrosky DT |title=Physician assistant : a guide to clinical practice |date=2013 |publisher=Elsevier/Saunders |location=Philadelphia, PA |isbn=9781455723102 |edition=5th}}</ref>{{rp|144}}