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Synaptogenesis
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===== Netrin and FLRTs signaling pathways ===== NTNs and FLRTs both act as guidance cues. NTNs may act as attractants or repellents by DCC and neogenin1, or repellants by UNC5 receptors. UNC5s also act as repulsive receptors for FLRTs. Besides guidance cues, NTNs and FLRTs are also involved in synaptic specificity and synaptogenesis.<ref name=":0" /> In studying [[Netrin]], one study found that Netrin is not needed for long-range guidance decision, but is used for short-range synaptic targeting. This was determined from studying an RP3 axon, which expresses Netrin as an axonal guidance cue. In gene knockout studies of Netrin, the RP3 growth cone still formed the correct synapses but the connections were not strong.<ref>{{cite journal | vauthors = Mitchell KJ, Doyle JL, Serafini T, Kennedy TE, Tessier-Lavigne M, Goodman CS, Dickson BJ | title = Genetic analysis of Netrin genes in Drosophila: Netrins guide CNS commissural axons and peripheral motor axons | journal = Neuron | volume = 17 | issue = 2 | pages = 203β215 | date = August 1996 | pmid = 8780645 | doi = 10.1016/s0896-6273(00)80153-1 }}</ref>
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