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Toxin
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==Research== In general, when scientists determine the amount of a substance that may be hazardous for humans, animals and/or the environment they determine the amount of the substance likely to trigger effects and if possible establish a safe level. In Europe, the [[European Food Safety Authority]] produced risk assessments for more than 4,000 substances in over 1,600 scientific opinions and they provide open access summaries of human health, animal health and ecological hazard assessments in their OpenFoodTox<ref>{{Cite web|url=https://www.efsa.europa.eu/en/data/chemical-hazards-data|title=Chemical hazards data - OpenFoodTox|website=European Food Safety Authority|language=en|access-date=2019-10-27}}</ref> database.<ref>{{cite journal | vauthors = Dorne JL, Richardson J, Kass G, Georgiadis N, Monguidi M, Pasinato L, Cappe S, Verhagen H, Robinson T | title = OpenFoodTox: EFSA's open source toxicological database on chemical hazards in food and feed. | journal = EFSA Journal | date = January 2017 | volume = 15 | issue = 1 | pages = e15011 | doi = 10.2903/j.efsa.2017.e15011 | pmid = 32625280 | pmc = 7009813 | doi-access = free }}</ref><ref name="pmid31325634">{{cite journal | vauthors = Reilly L, Serafimova R, Partosch F, Gundert-Remy U, Cortiñas Abrahantes J, Dorne JM, Kass GE | title = Testing the thresholds of toxicological concern values using a new database for food-related substances | journal = Toxicology Letters | volume = 314 | pages = 117–123 | date = October 2019 | pmid = 31325634 | doi = 10.1016/j.toxlet.2019.07.019 | doi-access = free }}</ref> The OpenFoodTox database can be used to screen potential new foods for toxicity.<ref>{{cite journal | vauthors = Pearce JM, Khaksari M, Denkenberger D | title = Preliminary Automated Determination of Edibility of Alternative Foods: Non-Targeted Screening for Toxins in Red Maple Leaf Concentrate | journal = Plants | volume = 8 | issue = 5 | pages = 110 | date = April 2019 | pmid = 31027336 | pmc = 6571818 | doi = 10.3390/plants8050110 | doi-access = free | bibcode = 2019Plnts...8..110P }}</ref> The Toxicology and Environmental Health Information Program (TEHIP)<ref>{{cite web|url=http://sis.nlm.nih.gov/enviro.html|title=Environmental Health and Toxicology Information|work=National Library of Medicine|access-date=29 September 2010|archive-date=1 September 2018|archive-url=https://web.archive.org/web/20180901172235/https://sis.nlm.nih.gov/enviro.html|url-status=dead}}</ref> at the [[United States National Library of Medicine]] (NLM) maintains a comprehensive toxicology and environmental health web site that includes access to toxins-related resources produced by TEHIP and by other government agencies and organizations.<ref name="Fonger_2000">{{cite journal | vauthors = Fonger GC, Stroup D, Thomas PL, Wexler P | title = TOXNET: A computerized collection of toxicological and environmental health information | journal = Toxicology and Industrial Health | volume = 16 | issue = 1 | pages = 4–6 | date = January 2000 | pmid = 10798381 | doi = 10.1177/074823370001600101 | bibcode = 2000ToxIH..16....4F | s2cid = 34029729 }}</ref> This web site includes links to databases, bibliographies, tutorials, and other scientific and consumer-oriented resources. TEHIP also is responsible for the Toxicology Data Network (TOXNET),<ref>{{cite web |url=http://toxnet.nlm.nih.gov/ |title=TOXNET |website=toxnet.nlm.nih.gov |access-date=29 September 2010 |archive-url=https://web.archive.org/web/20190514171418/https://toxnet.nlm.nih.gov/ |archive-date=14 May 2019 |url-status=dead }}</ref> an integrated system of toxicology and environmental health databases that are available free of charge on the web. [[TOXMAP]] is a Geographic Information System (GIS) that is part of TOXNET.<ref>{{cite journal | vauthors = Hochstein C, Szczur M | title = TOXMAP: a GIS-based gateway to environmental health resources | journal = Medical Reference Services Quarterly | volume = 25 | issue = 3 | pages = 13–31 | date = 2006-07-24 | pmid = 16893844 | pmc = 2703818 | doi = 10.1300/J115v25n03_02 }}</ref> TOXMAP uses maps of the United States to help users visually explore data from the [[United States Environmental Protection Agency]]'s (EPA) [[Toxics Release Inventory]] and [[Superfund Basic Research Program]]s.
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