Editing Transient receptor potential channel (section)

===TRPM===
{| class="wikitable"
!Family !!Sub-Family !! Known Taxa
|-
|rowspan="2" |TRPM
|Alpha/α (inc. TRPM1, 3, 6, and 7)
| rowspan="2"|All [[choanoflagellate]]s and [[eumetazoa]] (except [[tardigrades]])
|-
|Beta/β (inc. TRPM2, 4, 5, and 8)
|}
TRPM, M for "melastatin", was found during a comparative genetic analysis between benign [[Nevus|nevi]] and malignant nevi (melanoma).<ref name=":4" /> Mutations within TRPM channels have been associated with hypomagnesemia with secondary hypocalcemia. TRPM channels have also become known for their cold-sensing mechanisms, such is the case with TRPM8.<ref name=":3" />  Comparative studies have shown that the functional domains and critical amino acids of TRPM channels are highly conserved across species.<ref>{{cite journal |vauthors=Mederos y Schnitzler M, Wäring J, Gudermann T, Chubanov V |date=May 2008 |title=Evolutionary determinants of divergent calcium selectivity of TRPM channels |journal=FASEB Journal |volume=22 |issue=5 |pages=1540–51 |doi=10.1096/fj.07-9694com |doi-access=free |pmid=18073331 |s2cid=25474094}}</ref><ref name="Drosophila menthol sensitivity" /><ref>{{cite journal |vauthors=Iordanov I, Tóth B, Szollosi A, Csanády L |date=April 2019 |title=Enzyme activity and selectivity filter stability of ancient TRPM2 channels were simultaneously lost in early vertebrates |journal=eLife |volume=8 |doi=10.7554/eLife.44556 |pmc=6461439 |pmid=30938679 |doi-access=free }}</ref>

[[Phylogenetics]] has shown that TRPM channels are split into two major clades, αTRPM and βTRPM.<ref name="Drosophila menthol sensitivity" /><ref name="Himmel2" /> αTRPMs include vertebrate TRPM1, TRPM3, and the "chanzymes" TRPM6 and TRPM7, as well as the only insect TRPM channel, among others. βTRPMs include, but are not limited to, vertebrate TRPM2, TRPM4, TRPM5, and TRPM8 (the cold and menthol sensor).  Two additional major clades have been described: TRPMc, which is present only in a variety of arthropods,<ref name="Himmel2" /> and a basal clade,<ref name="Peng" /><ref name="Drosophila menthol sensitivity" /> which has since been proposed to be a distinct and separate TRP channel family (TRPS).<ref name="Himmel2" />