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Trigeminal neuralgia
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===Medical=== * The [[anticonvulsant]] [[carbamazepine]] is the first line treatment; second line medications include [[baclofen]], [[lamotrigine]], [[oxcarbazepine]], [[phenytoin]], [[topiramate]], [[gabapentin]] and [[pregabalin]]. Uncontrolled trials have suggested that [[clonazepam]] and [[lidocaine]] may be effective.<ref name=Sindrup2002>{{cite journal | vauthors = Sindrup SH, Jensen TS | title = Pharmacotherapy of trigeminal neuralgia | journal = The Clinical Journal of Pain | volume = 18 | issue = 1 | pages = 22β27 | year = 2002 | pmid = 11803299 | doi = 10.1097/00002508-200201000-00004 | s2cid = 24407923 }}</ref> * Antidepressant medications, such as [[amitriptyline]] have shown good efficacy in treating trigeminal neuralgia, especially if combined with an anti-convulsant drug such as pregabalin.<ref>{{cite journal| vauthors = Ahmed OL, Akinyele OA, Akindayo OA, Bamidele K |title=Management of Trigeminal Neuralgia using Amitriptyline and Pregablin combination Therapy|url=http://www.bioline.org.br/pdf?md12033|journal=African Journal of Biomedical Research|date=September 2012|volume=15|number=1|pages=201β203|display-authors=etal|url-status=live|archive-url=https://web.archive.org/web/20160822053222/http://www.bioline.org.br/pdf?md12033|archive-date=2016-08-22}}</ref> * There is some evidence that [[duloxetine]] can also be used in some cases of neuropathic pain, especially in patients with major depressive disorder<ref>{{cite journal | vauthors = Hsu CC, Chang CW, Peng CH, Liang CS | title = Rapid Management of Trigeminal Neuralgia and Comorbid Major Depressive Disorder With Duloxetine | journal = The Annals of Pharmacotherapy | volume = 48 | issue = 8 | pages = 1090β1092 | date = August 2014 | pmid = 24788987 | doi = 10.1177/1060028014532789 | s2cid = 38592913 }}</ref> as it is an antidepressant. However, it should, by no means, be considered a first line therapy and should only be tried by specialist advice.<ref>{{cite journal | vauthors = Lunn MP, Hughes RA, Wiffen PJ | title = Duloxetine for treating painful neuropathy, chronic pain or fibromyalgia | journal = The Cochrane Database of Systematic Reviews | volume = 2014 | issue = 1 | pages = CD007115 | date = January 2014 | pmid = 24385423 | pmc = 10711341 | doi = 10.1002/14651858.CD007115.pub3 }}</ref> * There is controversy around opiate use such as [[morphine]] and [[oxycodone]] for treatment of TN, with varying evidence on its effectiveness for neuropathic pain. Generally, opioids are considered ineffective against TN and thus should not be prescribed.<ref>{{cite journal | vauthors = Zakrzewska JM, Linskey ME | title = Trigeminal neuralgia | journal = BMJ | volume = 348 | issue = feb17 9 | pages = g474 | date = February 2014 | pmid = 24534115 | doi = 10.1136/bmj.g474 | url = http://www.bmj.com/bmj/section-pdf/752707?path=/bmj/348/7946/Clinical_Review.full.pdf | url-status = live | s2cid = 45305211 | archive-url = https://web.archive.org/web/20161220132327/http://www.bmj.com/bmj/section-pdf/752707?path=%2Fbmj%2F348%2F7946%2FClinical_Review.full.pdf | archive-date = 20 December 2016 }}</ref>
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