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Tumor necrosis factor
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=== Location === The human TNF [[gene]] is mapped to [[chromosome 6]]p21.3, residing in the [[MHC class III|class III]] region of the [[major histocompatibility complex]], where many immune system genes are contained. The class III region is sandwiched between the [[HLA-DR]] locus on the centromeric side, and the [[HLA-B]] locus on the telomeric side. The TNF gene is 250 kilobases away from the HLA-B locus, and 850 kilobases away from the HLA-DR locus. The TNF gene is located 1,100 kilobases downstream of the [[lymphotoxin alpha|lymphotoxin-Ξ±]] gene.<ref name="pmid11040201">{{cite journal | vauthors = Papadakis KA, Targan SR | title = Tumor necrosis factor: biology and therapeutic inhibitors | journal = Gastroenterology | volume = 119 | issue = 4 | pages = 1148β1157 | date = October 2000 | pmid = 11040201 | doi = 10.1053/gast.2000.18160 | doi-access = free }}</ref>
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