Editing Unibrow (section)

=== Medical conditions ===
A unibrow is part of normal human variation, but can also stem from developmental disorders. A unibrow is a recognized feature of [[Cornelia De Lange syndrome]], a genetic disorder whose main features include moderate to severe learning difficulties, limb abnormalities such as [[oligodactyly]] (fewer than normal fingers or toes), and [[phocomelia]] (malformed limbs), and facial abnormalities including a long [[philtrum]] (the slight depression/line between the nose and mouth).

Other medical conditions associated with a unibrow include:<ref>{{Cite web |title=Synophrys (Concept Id: C0431447) |url=https://www.ncbi.nlm.nih.gov/medgen/?term=unibrow |access-date=2023-12-01 |website=www.ncbi.nlm.nih.gov |language=en}}</ref>

* [[Michels syndrome|3MC syndrome 1]]
* [[Cantú syndrome|Acromegaloid facial appearance syndrome]]
* [[Acromesomelic dysplasia]] 4
* [[Amaurosis]]-[[hypertrichosis]] syndrome
* [[Arrhinia]] with [[choanal atresia]] and [[microphthalmia]] syndrome
* [[Dominance (genetics)|Autosomal recessive]] [[spinocerebellar ataxia]] 17
* [[Blepharophimosis intellectual disability syndromes|Blepharophimosis-impaired intellectual development syndrome]]
* [[Blepharophimosis-ptosis-esotropia-syndactyly-short stature syndrome]]
* [[Brachycephaly]], [[trichomegaly]], and [[Global developmental delay|developmental delay]]
* [[1p36 deletion syndrome|Chromosome 1p36 deletion syndrome]]
* [[Coffin–Siris syndrome|Coffin-Siris syndrome]] 12
* [[Cognitive impairment]] – [[Coarse facial features|coarse facies]] – [[Congenital heart defect|heart defects]] – [[obesity]] – pulmonary involvement – [[short stature]] – [[skeletal dysplasia]] syndrome
* [[Cornelia de Lange syndrome|Congenital muscular hypertrophy-cerebral syndrome]]
[[File:De Lange Syndrome 3.jpg|thumb|Unibrow in Cornelia de Lange syndrome]]
* [[Cornelia de Lange syndrome]] 1–5
* [[Proud syndrome|Corpus callosum agenesis-abnormal genitalia syndrome]]
* [[Cortical dysplasia]], complex, with other brain malformations 11
* [[Deafness]], [[cataract]], impaired [[Cognitive development|intellectual development]], and [[polyneuropathy]]
* [[Transaldolase deficiency|Deficiency of transaldolase]]
* [[DeSanto-Shinawi syndrome]] due to [[WAC (gene)|WAC]] [[point mutation]]
* Developmental and epileptic [[encephalopathy]] 23, 66, 83, 84, 85 (with or without midline brain defects), 100, and 105 (with [[hypopituitarism]])
* [[Global developmental delay|Developmental delay]] with variable [[intellectual disability]] and [[Dysmorphic feature|dysmorphic facies]]
* Developmental delay, [[Speech disorder|impaired speech]], and [[Abnormality (behavior)|behavioral abnormalities]]
* [[Diamond–Blackfan anemia|Diamond-Blackfan anemia]] 21
* Early-onset progressive diffuse [[Cerebral atrophy|brain atrophy]]-[[microcephaly]]-[[muscle weakness]]-[[Optic neuropathy|optic atrophy]] syndrome
* [[Epilepsy]], [[Sex linkage|X-linked]] 2, with or without impaired intellectual development and dysmorphic features
* Epilepsy-[[telangiectasia]] syndrome
* [[Focal segmental glomerulosclerosis]] and neurodevelopmental syndrome
* Fontaine [[Progeroid syndromes|progeroid syndrome]]
* [[Shprintzen–Goldberg syndrome|Goldberg-Shprintzen megacolon syndrome]]
* [[Child development|Growth delay]] due to [[Insulin-like growth factor 1|insulin-like growth factor I]] resistance
* [[Hajdu–Cheney syndrome|Hajdu-Cheney syndrome]]
* [[Hennekam syndrome|Hennekam lymphangiectasia-lymphedema syndrome]] 3
* [[Holoprosencephaly]] 5, 7, and 11
[[File:Amentia Plate XX (2).jpg|thumb|[[Hydrocephalic]] man with a unibrow]]
* [[Hypotonia]], [[ataxia]], and delayed development syndrome
* [[Intellectual disability|Intellectual developmental disorder]] 61
* Intellectual developmental disorder with or without [[peripheral neuropathy]]
* Intellectual developmental disorder, [[Dominance (genetics)|autosomal dominant]] 64 and 65
* Intellectual developmental disorder, autosomal recessive 68
* [[X-linked intellectual disability|Intellectual developmental disorder, X-linked]], syndromic, with pigmentary [[Mosaic (genetics)|mosaicism]] and coarse facies
* Intellectual disability, autosomal dominant 29, 30, 34, 43, 48, and 52
* Intellectual disability, autosomal recessive 5, 13, 16, 45, 46, and 61
* [[X-linked intellectual disability|Intellectual disability, X-linked]] 21, 73, 97, and 106
* Intellectual disability, X-linked, syndromic 33
* Intellectual disability-[[brachydactyly]]-[[Pierre Robin sequence|Pierre Robin syndrome]]
* Intellectual disability-facial dysmorphism syndrome due to [[SETD5]] [[haploinsufficiency]]
* [[Joubert syndrome]] 35
* [[KBG syndrome]]
* [[9q34.3 deletion syndrome|Kleefstra syndrome]] 1
* [[Lissencephaly]] 6 with microcephaly
* [[Giant platelet disorder|Macrothrombocytopenia]]-[[lymphedema]]-developmental delay-facial dysmorphism-[[camptodactyly]] syndrome
* [[Mandibulofacial dysostosis]]-macroblepharon-[[macrostomia]] syndrome
* [[Marshall–Smith syndrome|Marshall-Smith syndrome]]
* Microcephaly 4, primary, autosomal recessive
* Midface hypoplasia, [[Hearing loss|hearing impairment]], [[Hereditary elliptocytosis|elliptocytosis]], and [[nephrocalcinosis]]
* [[Mitochondrial complex IV|Mitochondrial complex 4]] deficiency, nuclear type 20
* [[Coenzyme Q – cytochrome c reductase|Mitochondrial complex III]] deficiency nuclear type 7
[[File:Mucopolysaccharidosis (Sanfilippo Syndrome) 1.jpg|thumb|Unibrow in MPS-III]]
* [[Sanfilippo syndrome|Mucopolysaccharidosis, MPS-III]]-A to -D
* [[Neurodevelopmental disorder]] with dysmorphic facies and variable [[seizure]]s
* Neurodevelopmental disorder with facial dysmorphism, [[Muteness|absent language]], and pseudo-[[Pelger–Huët anomaly|pelger-huet anomaly]]
* Neurodevelopmental disorder with [[Delayed milestone|growth retardation]], dysmorphic facies, and corpus callosum abnormalities
* Neurodevelopmental disorder with microcephaly, short stature, and [[speech delay]]
* Neurodevelopmental disorder with severe [[Physical disability|motor impairment]] and absent language
* Neurodevelopmental disorder with [[spasticity]] and poor growth
* Neurodevelopmental disorder with spasticity, [[cataract]]s, and [[cerebellar hypoplasia]]
* [[Gray matter heterotopia|Periventricular nodular heterotopia]] 9
* [[Pontocerebellar hypoplasia]] type 7, 8, and 10
* [[Primrose syndrome]]
* Severe [[Dysphagia|feeding difficulties]]-[[failure to thrive]]-microcephaly due to [[ASXL3]] deficiency syndrome
* [[Sialuria]]
* [[Skin fold|Skin creases]], congenital symmetric circumferential, 2
* [[Smith–Magenis syndrome|Smith-Magenis syndrome]]
* [[Spondyloepimetaphyseal dysplasia]], Genevieve type
* [[Spondyloepiphyseal dysplasia congenita|Spondyloepiphyseal dysplasia]], [[sensorineural hearing loss]], impaired [[Cognitive development|intellectual development]], and [[leber congenital amaurosis]]
* Syndromic [[X-linked intellectual disability]] Chudley-Schwartz type
* Syndromic X-linked intellectual disability Nascimento type
* Syndromic X-linked intellectual disability Siderius type
* Syndromic X-linked intellectual disability Snyder type
* [[Trigonocephaly]] 1
* Uruguay Faciocardiomusculoskeletal syndrome
* [[Waardenburg syndrome]] types 1, 2A, and 3
* [[Wiedemann–Steiner syndrome|Wiedemann-Steiner syndrome]]
* [[Zimmermann–Laband syndrome|Zimmermann-Laband syndrome]] 1, 2, and 3