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Modafinil
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===Myotonic dystrophy=== Modafinil is being researched as a potential remedy for excessive daytime sleepiness in [[myotonic dystrophy]] (DM), an inherited condition characterized by progressive muscle loss, weakness, and [[myotonia.]] Myotonia is a condition where muscles cannot relax after they contract.<ref name="pmid39011358">{{cite journal |vauthors=Hoxhaj D, Pascazio A, Maestri M, Ricci G, Fabbrini M, Torresi FB, Siciliano G, Bonanni E |title=Excessive daytime sleepiness in myotonic dystrophy: a narrative review |journal=Front Neurol |volume=15 |issue= |pages=1389949 |date=2024 |pmid=39011358 |pmc=11248093 |doi=10.3389/fneur.2024.1389949|doi-access=free }}</ref> Myotonic dystrophy has two main types: DM1 (Steinert disease) and DM2 (proximal myotonic myopathy). Both types can cause excessive daytime sleepiness. Studies suggest that modafinil may be a promising drug that can reduce both daytime sleepiness and myotonia itself, without significant cardiac conduction effects. These presumed property of modafinil is of particular interest for eventual treatment of people with myotonic dystrophy who often have underlying cardiac issues.<ref name="pmid39011358"/> Still, modafinil is not approved by the FDA for use in myotonic dystrophy, and the value and role of modafinil in DM remain the subject of debate.<ref name="pmid39011358"/>
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