Editing Doctor Octopus (section)

==== ''Marvel's Spider-Man'' series ====
Otto Octavius appears in [[Insomniac Games]]' ''[[Spider-Man (Insomniac Games series)|Marvel's Spider-Man]]'' series, voiced by [[William Salyers]].<ref>{{cite web |url=https://screenrant.com/spider-man-ps4-ending-explained/ |title=Marvel's Spider-Man PS4 Ending Explained |last=Mithaiwala |first=Mansoor |date=September 6, 2018 |website=[[Screen Rant]] |publisher=Valnet Inc. |access-date=September 7, 2018}}</ref><ref name="TVoDO" /> Once a close friend of [[Norman Osborn]] and co-founder of Oscorp, this version left the company due to its unethical genetic experiments. Founding his own company, Octavius Industries, he worked to perfect prosthetic limb technology, motivated by a neurological disorder he was developing. Octavius later employed [[Peter Parker (Insomniac Games character)|Peter Parker]], whom he mentored, as his lab assistant and eventually became aware of his activities as Spider-Man, but chose to hide this from him.
* First appearing as the final boss of ''[[Spider-Man (2018 video game)|Marvel's Spider-Man]]'' (2018), Octavius gains support from [[Advanced Idea Mechanics|A.I.M.]] after Norman exploits his position as mayor to remove Octavius' grant funding in an attempt to persuade him to return to Oscorp. During this time, Octavius befriends [[Mister Negative|Martin Li]], a victim of Oscorp's experimentation who has been leading terrorist attacks against the city to destroy Norman, inspiring Octavius to pursue his own vendetta against his former friend. While working on a set of mechanical thought-controlled tentacles with Parker, Octavius loses control of his emotions due to a defect with the neural implant used to connect them directly to his nervous system and causes a mass prison break from [[Ryker's Island]] and the [[Raft (comics)|Raft]]. Forming the [[Sinister Six]] with Li and several of Spider-Man's foes, Octavius, now going by "Doctor Octopus", organizes a series of attacks on Oscorp-owned properties and releases their Devil's Breath virus on New York in the hopes of exposing Norman's crimes. After capturing and nearly killing Norman, Octavius is confronted by Parker as Spider-Man, who rescues Norman and battles Octavius atop Oscorp tower, during which the latter reveals his knowledge of Parker's double life. Following his defeat, Octavius pleads for help, claiming the tentacles' artificial intelligence was in control of his actions, but a heartbroken Parker leaves him to face justice for his crimes, leading to Octavius' imprisonment at the Raft and Octavius Industries being shut down.
* Octavius makes a cameo appearance in a flashback depicted in ''[[Spider-Man: Miles Morales]]''.<ref>{{cite web | url=https://screenrant.com/spider-man-miles-morales-doctor-octopus-cameo-explained/ | title=Spider-Man: Miles Morales' Doctor Octopus Cameo Explained | website=[[Screen Rant]] | date=November 21, 2020}}</ref>
* Octavius makes a cameo appearance in the mid-credits scene of ''[[Marvel's Spider-Man 2]]'' (2023).<ref>{{cite web | url=https://www.ign.com/articles/spider-man-2-ending-explained-insomniac-sequel-green-goblin-silk | title=Spider-Man 2 Ending Explained: How Insomniac Sets up the Next Sequel | date=October 19, 2023}}</ref> Following the events of the main story, Norman visits his cell at the Raft to inquire about the Spider-Men's secret identities. Octavius taunts him with the belief that he needed to experience loss as he had while making preparations for the "final chapter".<ref>{{Cite web |last=Schedeen |first=Jesse |date=2023-10-19 |title=Spider-Man 2 Ending Explained: How Insomniac Sets Up the Next Sequel - IGN |url=https://www.ign.com/articles/spider-man-2-ending-explained-insomniac-sequel-green-goblin-silk |access-date=2023-10-19}}</ref> Additionally, the Superior Spider-Man's suit appears as an alternate skin for Peter.<ref>{{cite video game|title=[[Spider-Man 2]]|developer=[[Insomniac Games]] |publisher=[[Sony Interactive Entertainment]]|date=2023}}</ref>