Editing Protein engineering (section)

====Degenerate homo-duplex recombination (DHR)====
This method begins with alignment of homologous genes, followed by identification of regions of polymorphism. Next the top strand of the gene is divided into small degenerate oligonucleotides. The bottom strand is also digested into oligonucleotides to serve as scaffolds. These fragments are combined in solution are top strand oligonucleotides are assembled onto bottom strand oligonucleotides. Gaps between these fragments are filled with polymerase and ligated.<ref name=PoluriBook/>{{page needed|date=May 2017}}