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==Medicine== * October 13 – In [[Japan]], [[Hanaoka Seishū]] (華岡 青洲) performs a partial [[mastectomy]] for [[breast cancer]] on a 60-year-old woman named Kan Aiya, using tsūsensan as a [[general anesthetic]], generally regarded as the first reliably documented operation performed under general anesthesia.<ref>{{cite journal|last=Izuo|first=M.|title=Medical history: Seishū Hanaoka and his success in breast cancer surgery under general anesthesia two hundred years ago|journal=Breast Cancer|volume=11|issue=4|pages=319–24|year=2004|doi=10.1007/BF02968037|pmid=15604985|s2cid=43428862}}</ref><ref>{{cite book|title=The Pain Clinic IV: proceedings of the fourth international symposium|chapter=Doctor S. Hanaoka, the world's-first success in providing general anesthesia|pages=3–12|author=Hyodo, M.|editor1=Hyodo, M. |editor2=Oyama, T. |editor3=Swerdlow, M. |publisher=VSP|location=Utrecht|year=1992|isbn=90-6764-147-2|chapter-url=https://books.google.com/books?id=ljBTn8HBBjcC&q=%22Doctor%20S.%20Hanaoka%2C%20the%20World's-First%20Success%20in%20Providing%20General%20Anesthesia%22&pg=PA3|accessdate=2010-09-13}}</ref><ref>{{cite book|title=Giving up the gun: Japan's reversion to the sword, 1543-1879|last=Perrin|first=Noel|authorlink=Noel Perrin|publisher=David R. Godine|location=Boston|year=1979|page=[https://archive.org/details/givingupgun00noel/page/86 86]|isbn=0-87923-773-2|url=https://archive.org/details/givingupgun00noel|url-access=registration|quote=Giving up the gun Noel Perrin.|accessdate=2010-09-13}}</ref><ref>{{cite journal|author=Matsuki, A.|title=New studies on the history of anesthesiology – a new study on Seishū Hanaoka's "Nyugan chiken roku" (a surgical experience with breast cancer)|journal=Masui: The Japanese Journal of Anesthesiology|volume=49|issue=9|pages=1038–43|year=2000|issn=0021-4892|pmid=11025965|url=http://www.biomedsearch.com/nih/New-studies-history-anesthesiology-new/11025965.html|accessdate=2010-09-13|archive-date=2016-04-23|archive-url=https://web.archive.org/web/20160423215313/http://www.biomedsearch.com/nih/New-studies-history-anesthesiology-new/11025965.html|url-status=dead}}</ref> * Publication of ''The Anatomy of the Human Body, vol. 3, Nervous System'' by [[Charles Bell]].<ref>{{cite ODNB|first=L. S.|last=Jacyna|title=Bell, Sir Charles (1774–1842)|year=2004|url=http://www.oxforddnb.com/view/article/1999|accessdate=2011-04-06|doi=10.1093/ref:odnb/1999}} </ref> * English physician [[Joseph Mason Cox]] publishes ''Practical Observations on Insanity; in which some suggestions are offered towards and improved mode of treating diseases of the mind, and some rules proposed which it is hoped may lead to a more humane and successful method of cure''.<ref>{{cite book|first=Joseph Mason|last=Cox|url=https://wellcomecollection.org/works/w7gdnmef|title=Practical Observations on Insanity|edition=2nd|year=1806|location=London|publisher=Baldwin|via=Wellcome Collection|accessdate=2023-07-30}}.</ref> * [[Antonio Scarpa]] publishes ''Riflessioni ed Osservazione anatomico-chirugiche sull' Aneurisma'', a classic text on [[aneurysm]]s.<ref>{{cite journal|first=Benjamin Ward|last=Richardson|title=Antonio Scarpa, F.R.S., and Surgical Anatomy|journal=The Asclepiad|year=1886|volume=4|issue=16|pages=128–157|url=https://books.google.com/books?id=-xVCQGjm3ZEC|accessdate=2008-06-10|publisher=Longmans, Green and Co.|location=London}}</ref>
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