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Benzophenone
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==Commercially significant derivatives and analogues== There are over 300 natural benzophenones, with great structural diversity and biological activities. They are being investigated as potential sources of new drugs. <ref>{{Cite journal|last1=Wu|first1=Shi-Biao|last2=Long|first2=Chunlin|last3=Kennelly|first3=Edward J.|date=2014|title=Structural diversity and bioactivities of natural benzophenones|url=http://xlink.rsc.org/?DOI=C4NP00027G|journal=Nat. Prod. Rep.|language=en|volume=31|issue=9|pages=1158β1174|doi=10.1039/C4NP00027G|pmid=24972079|issn=0265-0568|url-access=subscription}}</ref> [[Substitution (chemistry)|Substituted]] benzophenones such as [[oxybenzone]] and [[dioxybenzone]] are used in many [[sunscreen]]s. The use of benzophenone-derivatives which structurally resemble a strong [[photosensitizer]] has been criticized (see [[sunscreen controversy]]). [[Michler's ketone]] has [[aniline|dimethylamino]] [[substituent]]s at each [[aromatic para position|''para'' position]]. The high-strength polymer [[PEEK]] is prepared from derivatives of benzophenone. [[2-Amino-5-chlorobenzophenone]] is used in the synthesis of [[Benzodiazepine|benzodiazepines]].<ref>{{Cite journal |last1=Massah |first1=Ahmad R. |last2=Gharaghani |first2=Sajjad |last3=Lordejani |first3=Hamid Ardeshiri |last4=Asakere |first4=Nahad |date=2016-08-01 |title=New and mild method for the synthesis of alprazolam and diazepam and computational study of their binding mode to GABAA receptor |url=https://doi.org/10.1007/s00044-016-1585-z |journal=Medicinal Chemistry Research |language=en |volume=25 |issue=8 |pages=1538β1550 |doi=10.1007/s00044-016-1585-z |issn=1554-8120|url-access=subscription }}</ref>
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