Editing Bronchiectasis (section)

=== Impaired host defenses ===
Impairments in host defenses that lead to bronchiectasis may be congenital, such as with [[primary ciliary dyskinesia]], or acquired, such as with the prolonged use of [[immunosuppressive drug]]s.<ref name=":02">{{Cite journal|last1=Chalmers|first1=James D.|last2=Chang|first2=Anne B.|last3=Chotirmall|first3=Sanjay H.|last4=Dhar|first4=Raja|last5=McShane|first5=Pamela J.|date=15 November 2018|title=Bronchiectasis|journal=Nature Reviews. Disease Primers|volume=4|issue=1|pages=45|doi=10.1038/s41572-018-0042-3 |pmid=30442957|s2cid=231984729}}</ref> Additionally, these impairments may be localized to the lungs, or systemic throughout the body. In these states of immunodeficiency, there is a weakened or absent [[immune system]] response to severe infections that repeatedly affect the lung and eventually result in bronchial wall injury.<ref>{{Cite journal|last1=Rook|first1=Mieneke|last2=Postma|first2=Dirkje S.|last3=van der Jagt|first3=Eric J.|last4=van Minnen|first4=Cees A.|last5=van der Heide|first5=Jaap J. Homan|last6=Ploeg|first6=Rutger J.|last7=van Son|first7=Willem J.|date=2006-01-27|title=Mycophenolate mofetil and bronchiectasis in kidney transplant patients: a possible relationship|journal=Transplantation|volume=81|issue=2|pages=287–9|doi=10.1097/01.tp.0000188638.28003.96 |pmid=16436974|s2cid=36043580 |doi-access=free}}</ref> [[HIV/AIDS]] is an example of an acquired immunodeficiency that can lead to the development of bronchiectasis.<ref>{{Cite journal|last1=Attia|first1=Engi F.|last2=Miller|first2=Robert F.|last3=Ferrand|first3=Rashida A.|date=February 2017|title=Bronchiectasis and other chronic lung diseases in adolescents living with HIV|journal=Current Opinion in Infectious Diseases|volume=30|issue=1|pages=21–30|doi=10.1097/QCO.0000000000000325 |pmc=5408733|pmid=27753690}}</ref>