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DNA-binding protein
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=== Design === Designing DNA-binding proteins that have a specified DNA-binding site has been an important goal for biotechnology. [[Zinc finger]] proteins have been designed to bind to specific DNA sequences and this is the basis of [[zinc finger nucleases]]. Recently [[Tal effector nuclease|transcription activator-like effector nucleases]] (TALENs) have been created which are based on natural [[protein]]s secreted by ''[[Xanthomonas]]'' bacteria via their [[Type three secretion system|type III secretion system]] when they infect various [[plant]] species.<ref name="pmid21929364">{{cite journal|vauthors=Clark KJ, Voytas DF, Ekker SC|date=September 2011|title=A TALE of two nucleases: gene targeting for the masses?|journal=Zebrafish|volume=8|issue=3|pages=147β9|doi=10.1089/zeb.2011.9993|pmc=3174730|pmid=21929364}}</ref>
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