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Delayed puberty
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==== Congenital disorders ==== Congenital diseases include untreated [[cryptorchidism]] where the [[testicle]]s fail to descend from the abdomen.<ref name=":2" /> Other congenital disorders are genetic in nature. In males, there can be deformities in the [[seminiferous tubule]] as in [[Klinefelter syndrome]] (most common cause in males),<ref name=":9">{{cite journal | vauthors = Villanueva C, Argente J | title = Pathology or normal variant: what constitutes a delay in puberty? | language = en | journal = Hormone Research in Paediatrics | volume = 82 | issue = 4 | pages = 213–21 | date = 2014 | pmid = 25011467 | doi = 10.1159/000362600 | s2cid = 23869989 | doi-access = free }}</ref> defects in the production of testicular steroids, receptor mutations preventing testicular hormones from working, chromosomal abnormalities such as [[Noonan syndrome]], or problems with the cells making up the testes.<ref name=":2" /> Females can also have chromosomal abnormalities such as [[Turner syndrome]] (most common cause in girls),<ref name=":9" /> [[XX gonadal dysgenesis]], and [[XY gonadal dysgenesis]], problems in the ovarian hormone synthesis pathway such as [[aromatase deficiency]]<ref name=":2" /> or congenital anatomical deformities such as [[Müllerian agenesis]].<ref name=":5" />
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