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Diethyl ether
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== Metabolism == A [[cytochrome P450]] enzyme is proposed to metabolize diethyl ether.<ref>[http://www.fgsc.net/asilomar1997/secmetab.html 109. Aspergillus flavus mutant strain 241, blocked in aflatoxin biosynthesis, does not accumulate aflR transcript.] {{Webarchive|url=https://web.archive.org/web/20170917080739/http://www.fgsc.net/asilomar1997/secmetab.html |date=2017-09-17 }} Matthew P. Brown and Gary A. Payne, [[North Carolina State University]], Raleigh, NC, fgsc.net</ref> Diethyl ether inhibits [[alcohol dehydrogenase]], and thus slows the metabolism of [[ethanol]].<ref>{{cite journal |author1=P. T. Normann |author2=A. Ripel |author3=J. Morland | title = Diethyl Ether Inhibits Ethanol Metabolism in Vivo by Interaction with Alcohol Dehydrogenase | year = 1987 | journal = [[Alcoholism: Clinical and Experimental Research]] | volume = 11 | issue = 2 | pages = 163β166 | doi = 10.1111/j.1530-0277.1987.tb01282.x | pmid=3296835}}</ref> It also inhibits metabolism of other drugs requiring [[oxidative metabolism]]. For example, [[diazepam]] requires hepatic oxidization whereas its oxidized metabolite [[oxazepam]] does not.<ref>{{cite journal | title = Inhibition of N-Nitrosodimethylamine Metabolism in Rats by Ether Anesthesia |author1=Larry K. Keefer |author2=William A. Garland |author3=Neil F. Oldfield |author4=James E. Swagzdis |author5=Bruce A. Mico | journal = [[Cancer Research (journal)|Cancer Research]] | volume = 45 | pages = 5457β5460 | year = 1985 | url = http://cancerres.aacrjournals.org/cgi/reprint/45/11_Part_1/5457.pdf | pmid=4053020 | issue = 11 Pt 1}}</ref>
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