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Electron ionization
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=== Vacuum manifold === In this method the sample is first inserted into a heated sample reservoir in the vacuum manifold. It then escapes into the ionization chamber through a pinhole. This method is useful with highly volatile samples that may not be compatible with other sample introduction methods.<ref>{{cite book|last1=Dass|first1=Chhabil|editor1-last=Desiderio|editor1-first=Dominic|editor2-last=Nibbering|editor2-first=Nico|title=Fundamentals of Contemporary Mass Spectrometry|date=2007|publisher=John Wiley & Sons, Inc.|location=Hoboken|page=19|edition=1|language=en}}</ref>
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