Editing Enantioselective synthesis (section)

===Enantioselective organocatalysis===
{{Main|Organocatalysis}}
Organocatalysis refers to a form of [[catalysis]], where the rate of a [[chemical reaction]] is increased by an [[organic compound]] consisting of [[carbon]], [[hydrogen]], [[sulfur]] and other non-metal elements.<ref>{{cite book | title=Asymmetric Organocatalysis|author1=Berkessel, A. |author2=Groeger, H. | year=2005| publisher=Wiley-VCH| location=Weinheim| isbn=3-527-30517-3}}</ref><ref name="Special_Issue_Chem_Rev">Special Issue: {{Cite journal | volume = 107 | issue = 12 | pages = 5413–5883 | first = Benjamin| last = List | title = Organocatalysis | journal = Chem. Rev. | year = 2007 | doi = 10.1021/cr078412e| doi-access = free }}</ref>
When the organocatalyst is [[Chirality (chemistry)|chiral]], then enantioselective synthesis can be achieved;<ref>{{cite book|last=Gröger|first=Albrecht Berkessel; Harald|title=Asymmetric organocatalysis – from biomimetic concepts to applications in asymmetric synthesis|year=2005|publisher=Wiley-VCH|location=Weinheim|isbn=3-527-30517-3|edition=1. ed., 2. reprint.}}</ref><ref>{{cite journal|last=Dalko|first=Peter I.|author2=Moisan, Lionel|title=Enantioselective Organocatalysis|journal=Angewandte Chemie International Edition|date=15 October 2001|volume=40|issue=20|pages=3726–3748|doi=10.1002/1521-3773(20011015)40:20<3726::AID-ANIE3726>3.0.CO;2-D|pmid=11668532}}</ref>
for example a number of carbon–carbon bond forming reactions become enantioselective in the presence of [[proline]] with the [[Aldol reaction#Organocatalysis|aldol reaction]] being a prime example.<ref>{{cite journal|last=Notz|first=Wolfgang|author2=Tanaka, Fujie |author3=Barbas, Carlos F. |title=Enamine-Based Organocatalysis with Proline and Diamines: The Development of Direct Catalytic Asymmetric Aldol, Mannich, Michael, and Diels−Alder Reactions|journal=Accounts of Chemical Research|date=1 August 2004|volume=37|issue=8|pages=580–591|doi=10.1021/ar0300468|pmid=15311957}}</ref>
Organocatalysis often employs natural compounds and [[secondary amine]]s as chiral catalysts;<ref>{{cite journal|last1=Bertelsen|first1=Søren|last2=Jørgensen|first2=Karl Anker|title=Organocatalysis—after the gold rush|journal=Chemical Society Reviews|date=2009|volume=38|issue=8|pages=2178–89|doi=10.1039/b903816g|pmid=19623342}}</ref> these are inexpensive and [[green chemistry|environmentally friendly]], as no metals are involved.