Editing Environmental factor (section)

==Related fields==
The concept of the exposome has contributed to the 2010 proposal of a new [[paradigm]] in disease [[phenotype]], "the unique disease principle": Every individual has a unique disease process different from any other individual, considering uniqueness of the exposome and its unique influence on molecular pathologic processes including alterations in the [[interactome]].<ref>{{cite journal | vauthors = Ogino S, Lochhead P, Chan AT, Nishihara R, Cho E, Wolpin BM, Meyerhardt JA, Meissner A, Schernhammer ES, Fuchs CS, Giovannucci E | display-authors = 6 | title = Molecular pathological epidemiology of epigenetics: emerging integrative science to analyze environment, host, and disease | journal = Modern Pathology | volume = 26 | issue = 4 | pages = 465–484 | date = April 2013 | pmid = 23307060 | pmc = 3637979 | doi = 10.1038/modpathol.2012.214 }}</ref> This principle was first described in neoplastic diseases as "the unique tumor principle".<ref>{{cite journal | vauthors = Ogino S, Fuchs CS, Giovannucci E | title = How many molecular subtypes? Implications of the unique tumor principle in personalized medicine | journal = Expert Review of Molecular Diagnostics | volume = 12 | issue = 6 | pages = 621–628 | date = July 2012 | pmid = 22845482 | pmc = 3492839 | doi = 10.1586/erm.12.46 }}</ref> Based on this unique disease principle, the interdisciplinary field of [[molecular pathological epidemiology]] (MPE) integrates [[molecular pathology]] and epidemiology.<ref>{{cite journal | vauthors = Ogino S, Stampfer M | title = Lifestyle factors and microsatellite instability in colorectal cancer: the evolving field of molecular pathological epidemiology | journal = Journal of the National Cancer Institute | volume = 102 | issue = 6 | pages = 365–367 | date = March 2010 | pmid = 20208016 | pmc = 2841039 | doi = 10.1093/jnci/djq031 }}</ref>