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Fight-or-flight response
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===Reaction=== The reaction begins in the [[amygdala]], which triggers a neural response in the [[hypothalamus]]. The initial reaction is followed by activation of the [[pituitary gland]] and secretion of the hormone [[Adrenocorticotropic hormone|ACTH]].<ref name="ACTH Action">{{cite web |last=Margioris |first=Andrew |title=ACTH Action on the Adrenal |url=http://www.endotext.org/adrenal/adrenal5/adrenal5.htm |publisher=Endotext.org |access-date=18 April 2013 |author2=Tsatsanis, Christos |date=April 2011 |url-status=dead |archive-url=https://web.archive.org/web/20130306182338/http://www.endotext.org/adrenal/adrenal5/adrenal5.htm |archive-date=6 March 2013 }}</ref> The [[adrenal gland]] is activated almost simultaneously, via the sympathetic nervous system, and releases the hormone [[epinephrine]]. The release of chemical messengers results in the production of the hormone [[cortisol]], which increases [[blood pressure]], [[blood sugar]], and suppresses the [[immune system]].<ref name="physiological reactions - Padgett & Glaser">{{cite journal|last=Padgett|first=David|author2=Glaser, R|title=How stress influences the immune response|journal=Trends in Immunology|date=August 2003|volume=24|issue=8|pages=444β448|doi=10.1016/S1471-4906(03)00173-X|pmid=12909458|citeseerx=10.1.1.467.1386}}</ref> The initial response and subsequent reactions are triggered in an effort to create a boost of energy. This boost of energy is activated by epinephrine binding to [[cells (biology)|liver cells]] and the subsequent production of [[glucose]].<ref name="Glycogen Metabolism - King">{{cite web |last=King |first=Michael |title=PATHWAYS: GLYCOGEN & GLUCOSE |url=http://neuromuscular.wustl.edu/pathol/diagrams/glycogen.htm |publisher=[[Washington University in St. Louis]]}}</ref> Additionally, the circulation of cortisol functions to turn [[fatty acids]] into available energy, which prepares muscles throughout the body for response.<ref name="Cell Communication in Fight or Flight">{{cite web |title=HOW CELLS COMMUNICATE DURING THE FIGHT OR FLIGHT RESPONSE |url=http://learn.genetics.utah.edu/content/begin/cells/fight_flight/ |publisher=University of Utah |access-date=18 April 2013 |url-status=dead |archive-url=https://web.archive.org/web/20130808004906/http://learn.genetics.utah.edu/content/begin/cells/fight_flight/ |archive-date=8 August 2013 }}</ref> Catecholamine hormones, such as [[Epinephrine|adrenaline]] ([[epinephrine]]) or [[noradrenaline]] (norepinephrine), facilitate immediate physical reactions associated with a preparation for violent [[muscular]] action.<ref name=gleitman>{{Cite book|author= [[Henry Gleitman]], Alan J. Fridlund and [[Daniel Reisberg]] |title= Psychology |edition= 6 |year= 2004 |publisher= [[W. W. Norton & Company]] |isbn= 978-0-393-97767-7 }}</ref>
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