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Food intolerance
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==Prevention== There is emerging evidence from studies of cord blood that both sensitization and the acquisition of tolerance can begin in pregnancy, however, the window of main danger for sensitization to foods extends prenatally, remaining most critical during early infancy when the immune system and intestinal tract are still maturing.{{Citation needed|date=May 2014}} There is no conclusive evidence to support the restriction of dairy intake in the maternal diet during pregnancy, and this is generally not recommended since the drawbacks in terms of loss of nutrition can out-weigh the benefits. However, further randomised, controlled trials are required to examine if dietary exclusion by lactating mothers can truly minimize risk to a significant degree and if any reduction in risk is out-weighed by deleterious impacts on maternal nutrition.<ref name="pmid16373958"> {{cite journal |vauthors=Crittenden RG, Bennett LE |s2cid=1325287 |title=Cow's milk allergy: a complex disorder |journal=J Am Coll Nutr |volume=24 |issue=6 Suppl |pages=582S–91S |date=December 2005 |pmid=16373958 |doi=10.1080/07315724.2005.10719507}}</ref> A Cochrane review has concluded feeding with a soy formula cannot be recommended for prevention of allergy or food intolerance in infants. Further research may be warranted to determine the role of soy formulas for prevention of allergy or food intolerance in infants unable to be breast fed with a strong family history of allergy or cow's milk protein intolerance.<ref name="pmid17054183"> {{cite journal |vauthors=Osborn DA, Sinn J|editor1-last=Sinn |editor1-first=John KH |title=Soy formula for prevention of allergy and food intolerance in infants |journal=Cochrane Database Syst Rev |issue=4 |pages=CD003741 |year=2006 |volume=2010 |pmid=17054183 |doi=10.1002/14651858.CD003741.pub4 |pmc=6885056 }}</ref> In the case of allergy and celiac disease others recommend a dietary regimen that is effective in the prevention of allergic diseases in high-risk infants, particularly in early infancy. The most effective dietary regimen is exclusive breastfeeding for at least 4–6 months or, in absence of breast milk, formulas with documented reduced allergenicity for at least the first 4 months, combined with avoidance of solid food and cow's milk for the first 4 months.<ref name="pmid18199086"> {{cite journal |author=Høst A |title=Dietary prevention of allergic diseases in infants and small children |journal=Pediatr Allergy Immunol |volume=19 |issue=1 |pages=1–4 |date=February 2008 |pmid=18199086 |doi=10.1111/j.1399-3038.2007.00680.x |name-list-style=vanc|author2=Halken S |author3=Muraro A |display-authors=3 |last4=Dreborg |first4=Sten |last5=Niggemann |first5=Bodo |last6=Aalberse |first6=Rob |last7=Arshad |first7=Syed H. |last8=Von Berg |first8=Andrea |last9=Carlsen |first9=Kai-Håkon|s2cid=8831420 }}</ref><ref name="pmid17308459"> {{cite journal |author=Chertok IR |s2cid=25021206 |title=The importance of exclusive breastfeeding in infants at risk for celiac disease |journal=MCN Am J Matern Child Nurs |volume=32 |issue=1 |pages=50–4; quiz 55–6 |year=2007 |pmid=17308459 |doi= 10.1097/00005721-200701000-00011}}</ref>
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