Editing Germ cell (section)

====The ''Sry'' gene of the Y chromosome====
The Sex-determining Region of the Y [[chromosome]] (''[[SRY]]'') directs male development in mammals by inducing the somatic cells of the gonadal ridge to develop into a testis, rather than an ovary.<ref name="Alberts">{{cite book |chapter=Primordial Germ Cells and Sex Determination in Mammals | chapter-url = https://www.ncbi.nlm.nih.gov/books/NBK26940/|title=Molecular Biology of the Cell. | edition = 4th . | vauthors = Alberts B, Johnson A, Lewis J, etal |publisher=Garland Science|year=2002}}</ref> ''Sry'' is expressed in a small group of [[somatic cell]]s of the gonads and influences these cells to become [[Sertoli cells]] (supporting cells in testis). Sertoli cells are responsible for sexual development along a male pathway in many ways. One of these ways involves stimulation of the arriving primordial cells to differentiate into [[sperm]]. In the absence of the ''Sry'' gene, primordial germ cells differentiate into [[egg (biology)|eggs]]. Removing genital ridges before they start to develop into [[testes]] or [[ovary|ovaries]] results in the development of a female, independent of the carried [[sex chromosome]].<ref name="Alberts"/>