Editing Germ layer (section)

===Mesoderm===
[[Image:Mesoderm.png|thumb|275px|The [[mesoderm]] aids in the production of [[cardiac muscle]], [[skeletal muscle]], [[smooth muscle]], tissues within the [[kidney]]s, and [[red blood cell]]s.]]
{{main|Mesoderm}}
The '''mesoderm''' germ layer forms in the [[embryo]]s of [[triploblastic]] [[animal]]s. During [[gastrulation]], some of the cells migrating inward contribute to the mesoderm, an additional layer between the endoderm and the [[ectoderm]].<ref>{{Citation |last1=Muhr |first1=Jeremy |title=Embryology, Gastrulation |date=2022 |url=http://www.ncbi.nlm.nih.gov/books/NBK554394/ |work=StatPearls |place=Treasure Island (FL) |publisher=StatPearls Publishing |pmid=32119281 |access-date=2022-02-27 |last2=Ackerman |first2=Kristin M.}}</ref> The formation of a mesoderm leads to the development of a [[coelom]]. Organs formed inside a coelom can freely move, grow, and develop independently of the body wall while fluid cushions protects them from shocks.<ref>{{Cite web |date=2017-06-07 |title=Coelom |url=https://biologydictionary.net/coelom/ |access-date=2022-02-23 |website=Biology Dictionary}}</ref>

The mesoderm has several components which develop into tissues: [[intermediate mesoderm]], [[paraxial mesoderm]], [[lateral plate mesoderm]], and [[Axial mesoderm|chorda-mesoderm]]. The chorda-mesoderm develops into the notochord. The intermediate mesoderm develops into kidneys and gonads. The paraxial mesoderm develops into cartilage, skeletal muscle, and dermis. The lateral plate mesoderm develops into the circulatory system (including the heart and spleen), the wall of the gut, and wall of the human body.<ref>{{cite book | title = Developmental Biology | chapter = Paraxial and Intermediate Mesoderm | first = Scott F | last = Gilbert | chapter-url = https://www.ncbi.nlm.nih.gov/books/NBK9997/ | publisher = Sinauer Associates | year = 2003}}</ref>

Through cell signaling cascades and interactions with the ectodermal and endodermal cells, the mesodermal cells begin the process of [[cellular differentiation|differentiation]].<ref name="Brand 2003">{{cite journal|last=Brand|first=Thomas|title=Heart development: molecular insights into cardiac specification and early morphogenesis|journal=Developmental Biology|date=1 June 2003|volume=258|issue=1|pages=1–19|doi=10.1016/S0012-1606(03)00112-X|pmid=12781678|doi-access=free}}</ref>

The mesoderm forms: muscle ([[Smooth muscle tissue|smooth]] and [[Striated muscle tissue|striated]]), [[bone]], [[cartilage]], [[connective tissue]], [[adipose tissue]], [[circulatory system]], [[lymphatic system]], [[dermis]], [[dentine]] of teeth, [[genitourinary system]], [[serous membrane]]s, [[spleen]] and [[notochord]].