Editing Hyperpigmentation (section)

===Oral===
Oral medication with [[procyanidin]] plus vitamins A, C, and E also shows promise as safe and effective for epidermal melasma. In an 8-week randomized, double-blind, placebo-controlled trial in 56 Filipino women, treatment was associated with significant improvements in the left and right malar regions, and was safe and well tolerated.<ref>{{Cite journal|last=Handog|first=Evangeline|date=2009-07-20|title=A randomized, double-blind, placebo-controlled trial of oral procyanidin with Vitamins A, C, E for melasma among Filipino women|journal=International Journal of Dermatology|volume=48|issue=8|pages=896–901|doi=10.1111/j.1365-4632.2009.04130.x|pmid=19659873|s2cid=28886093|doi-access=free}}</ref> Other treatments that do not involve topical agents are also available, including fraction lasers<ref>{{Cite web|url=http://skinwhiteningnews.org/laser-skin-whitening-advantages-and-disadvantages/|title=Laser Skin Whitening - Advantages and Disadvantages {{!}} Skin Whitening News|website=skinwhiteningnews.org|language=en-US|access-date=2017-02-12|date=2014-04-05|archive-date=2021-09-19|archive-url=https://web.archive.org/web/20210919172154/https://skinwhiteningnews.org/laser-skin-whitening-advantages-and-disadvantages/|url-status=dead}}</ref> and dermabrasion.<ref name=":0" />